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Article Dans Une Revue Cancers Année : 2021

Technological Advances in Tumor-On-Chip Technology: From Bench to Bedside

Alexandra Harrison
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  • PersonId : 1110897
Valérie Taly
Wenjin Xiao
  • Fonction : Auteur
  • PersonId : 1110898

Résumé

Tumor-on-chip technology has cemented its importance as an in vitro tumor model for cancer research. Its ability to recapitulate different elements of the in vivo tumor microenvironment makes it promising for translational medicine, with potential application in enabling personalized anti-cancer therapies. Here, we provide an overview of the current technological advances for tumor-on-chip generation. To further elevate the functionalities of the technology, these approaches need to be coupled with effective analysis tools. This aspect of tumor-on-chip technology is often neglected in the current literature. We address this shortcoming by reviewing state-of-the-art on-chip analysis tools for microfluidic tumor models. Lastly, we focus on the current progress in tumor-on-chip devices using patient-derived samples and evaluate their potential for clinical research and personalized medicine applications.

Domaines

Cancer
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Origine : Publication financée par une institution

Dates et versions

hal-03351357 , version 1 (22-09-2021)

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Santa Bērziņa, Alexandra Harrison, Valérie Taly, Wenjin Xiao. Technological Advances in Tumor-On-Chip Technology: From Bench to Bedside. Cancers, 2021, 13 (16), pp.4192. ⟨10.3390/cancers13164192⟩. ⟨hal-03351357⟩
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