Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes
Résumé
Graphical Abstract Highlights d Structural organization of cytohesins investigated by SEC-SAXS, NS-EM, DLS, and HDX-MS d Cytohesin dimers have an elongated and conformationally dynamic quaternary structure d Cytohesin dimers bind membranes using one PH domain at a time d Membrane binding perturbs the structural organization to prime allosteric activation
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