Skip to Main content Skip to Navigation
Preprints, Working Papers, ...

Differential cell fates of muscle stem cells are accompanied by symmetric segregation of canonical H3 histones in vivo

Abstract : Stem cells are maintained through symmetric or asymmetric cell divisions. While various mechanisms initiate asymmetric cell fates during mitosis, possible epigenetic control of this process has emerged recently. The asymmetrical distribution of a canonical histone H3 variant during mitosis in fly germline has suggested a role for partitioning old and new nucleosomes in asymmetric cell fates. Here, we provide resources for single cell assays and show the asymmetric segregation of transcription factors along with old and new DNA in mouse muscle stem cells ex vivo and in vivo . However, these differential fate outcomes contrast with a symmetric distribution of the canonical H3.1 vertebrate variant. These findings point to different evolutionary mechanisms operating in fly germline stem cells and vertebrate somatic stem cells to mitigate epigenetic regulation of asymmetric cell fates.
Document type :
Preprints, Working Papers, ...
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03052823
Contributor : Geneviève Almouzni Connect in order to contact the contributor
Submitted on : Thursday, December 10, 2020 - 6:00:07 PM
Last modification on : Tuesday, October 19, 2021 - 10:29:24 PM
Long-term archiving on: : Thursday, March 11, 2021 - 8:57:31 PM

File

Evano et al_biorxiv_2019.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Citation

Brendan Evano, Gilles Le Carrou, Geneviève Almouzni, Shahragim Tajbakhsh. Differential cell fates of muscle stem cells are accompanied by symmetric segregation of canonical H3 histones in vivo. 2017. ⟨hal-03052823⟩

Share

Metrics

Record views

88

Files downloads

148