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Label-free discrimination of human lymphoma cell sub-populations with microwave dielectric spectroscopy

Abstract : This paper deals with the label-free microwave die-lectric characterization of B lymphoma cell lines, the OCI-LY7, OCI-LY10 and OCI-LY18 ones, and demonstrates that the technique is able to discriminate these three sub-population cell lines with their different dielectric properties. Proof is given that such a differentiation is not due to a variation of cell size, viability or cells concentration, but to internal molecular differences. This constitutes a major result as it demonstrates for the first time that microwave dielectric spectroscopy is sufficiently sensitive using di-electric properties variations to distinguish very similar biological cell lines of the same phenotype, B lymphoma cell lines in our case, whereas such a detection is traditionally performed with marker-based and costly equipment or using heavy genetic methods.
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https://hal.laas.fr/hal-01951446
Contributor : Katia Grenier <>
Submitted on : Tuesday, December 11, 2018 - 2:22:44 PM
Last modification on : Thursday, June 10, 2021 - 3:06:17 AM
Long-term archiving on: : Tuesday, March 12, 2019 - 2:37:48 PM

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  • HAL Id : hal-01951446, version 1

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Katia Grenier, François Artis, Mary Poupot, J-J Fournié, David Dubuc. Label-free discrimination of human lymphoma cell sub-populations with microwave dielectric spectroscopy. IEEE International Microwave Symposium (IMS 2018), Jun 2018, Philadelphie, PA, United States. 4p. ⟨hal-01951446⟩

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