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Microwave dielectric spectroscopy of cell membrane permeabilization with saponin on human B lymphoma cells

Abstract : This paper aims to contribute to the demonstration of the microwave dielectric spectroscopy relevance for biological applications. We demonstrate indeed that microwave dielectric spectroscopy may significantly identify the membrane permeabilization (and its consequence on cells) of cells induced by chemo-treatment. Standard deviations on both real and imaginary parts (resp.) of the permittivity between several experiments are below 0.08 and 0.06 (resp.), whereas the contrasts on these two parameters reach 1.92 and 1.30 (resp.) at 10 GHz. The contrasts to the standard deviation ratio are then above 22, which permits to convince the biologists that the technique can significantly and efficiently detect the viability state of a cells population in their traditional culture medium. Moreover, these results permits to predict that such a technique can evaluate the viability of a cells population with few percents of accuracy.
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https://hal.laas.fr/hal-01951717
Contributor : Katia Grenier <>
Submitted on : Tuesday, December 11, 2018 - 3:51:57 PM
Last modification on : Thursday, June 10, 2021 - 3:02:57 AM
Long-term archiving on: : Tuesday, March 12, 2019 - 3:01:13 PM

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  • HAL Id : hal-01951717, version 1

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François Artis, David Dubuc, Jean-Jacques Fournié, Mary Poupot, Katia Grenier. Microwave dielectric spectroscopy of cell membrane permeabilization with saponin on human B lymphoma cells. IEEE MTT-S International Microwave Symposium (IMS2014), Jun 2014, Tampa, United States. 4p. ⟨hal-01951717⟩

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