F. References-arduini, S. Cinti, V. Scognamiglio, D. Moscone, and G. Palleschi, Demonstration is performed through the study of algal photosynthetic metabolisms by using three different algae, i.e. Chlamydomonas reinhardtii, Pseudokirchneriella subcapitata and Chlorella vulgaris, and dealing with Diuron herbicide. Thus, the Diuron concentration increase is found to be responsible for an algal oxygen production inhibition as well as an algal red fluorescence enhancement. Finally, it is demonstrated that (i) the ElecCell and LED/OPD microsensor technologies are successfully adapted to the analysis of algae metabolisms, and (ii) that the associated DFR-LOC device is fully adapted to the electrochemical/optical dual detection for on-site pollutant analysis, i.e. without sample pre-treatment. Fully optical integration, that involves micro-cavity OLED as excitation light and OPD as detection device, is under progress. It will increase the optical sensor sensitivity. Further works will therefore imply the development of multi-algae/multisensor lab-on chip in order to deal with the selective detection of different pollutants, i.e. different herbicides in a frame of a "plug-and-play" system for water analysis, packaging technology based on the use of dry film resist (DFR), three-electrode electrochemical microcells (ElecCell) and an organic photodetectors (OPD) lead, in a functional way, to a DFR-LOC fully adapted to liquid phase analysis, pp.959-974, 2017.

R. Brayner, A. Couté, J. Livage, C. Perrette, and C. Sicard, Analytical and Bioanalytical Chemistry, vol.401, pp.581-597, 2011.

C. Christophe, F. Sékli-belaïdi, J. Launay, P. Gros, E. Questel et al., Sensors and Actuators, pp.177-350, 2013.

A. A. Fernandez-jaramillo, C. Duarte-galvan, L. M. Contreras-medina, I. Torres-pacheco, J. Romero-troncoso-r.-de et al., Biosensors and Bioelectronic, vol.117, pp.131-160, 1995.

M. Gunetti, S. Castiglia, D. Rustichelli, K. Mareschi1, F. Sanavio et al., Journal of Translational Medicine, vol.10, pp.112-123, 2012.

R. E. Ionescu, K. Abu-rabeah, S. Cosnier, C. Durrieu, J. M. Chovelon et al., Electroanal, vol.18, pp.1041-1046, 2006.

A. Jang, Z. Zou, K. Lee, K. Ahn, C. H. Bishop et al., Measurement Science and Technology, pp.22-23, 2011.

M. Kielar, O. Dhez, G. Pecastaings, A. Curutchet, and H. L. , Sci. Rep, vol.6, p.1, 2016.

F. Lefèvre, A. Chalifour, L. Yu, V. Chodavarapu, P. Juneau et al., Lab Chip, pp.12-787, 2012.

Y. Liang, Z. Xu, J. Xia, S. Tsai, Y. Wu et al., Advanced Materials, pp.22-135, 2010.

S. Belaidi, F. Tsopela, A. Salvagnac, L. Ventalon, V. Bedel-pereira et al., Nanotechnology Materials and Devices Conference, 9-12 October in, vol.46, pp.83-91, 1960.

Y. Sun, G. C. Welch, W. L. Leong, C. J. Takacs, G. C. Bazan et al., Nature Materials, vol.11, pp.44-48, 2012.

I. B. Tahirbegi, J. Ehgartner, P. Sulzer, S. Zieger, A. Kasjanow et al., Biosensors sand Bioelectronics, pp.88-188, 2017.

A. Tsopela, A. Lale, E. Vanhove, O. Reynes, I. Seguy et al., Biosensors and Bioelectronics, vol.61, pp.290-297, 2014.

A. Tsopela, A. Laborde, L. Salvagnac, V. Ventalon, E. Bedel-pereira et al., Biosensors and Bioelectronics, vol.79, pp.568-573, 2016.

E. Vanhove, A. Tsopela, L. Bouscayrol, A. Desmoulins, J. Launay et al., Sensors and Actuators, pp.178-350, 2013.