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Directions of work or proceedings, revue

Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology

Abstract : This review summarizes recent advances in micro- and nanopore technologies with a focus on thefunctionalization of pores using a promising method named contactless electro-functionalization (CLEF). CLEF enables the localized grafting of electroactive entities onto the inner wall of a microor nano-sized pore in a solid-state silicon/silicon oxide membrane. A voltage or electrical current applied across the pore induces the surface functionalization by electroactive entities exclusively on the inside pore wall, which is a significant improvement over existing methods. CLEF’s mechanism is based on the polarization of a sandwich-like silicon/silicon oxide membrane, creating electronic pathways between the core silicon and the electrolyte. Correlation between numerical simulations and experiments have validated this hypothesis. CLEF-induced micro-andnanopores functionalized with antibodies or oligonucleotides were successfully used for the detection and identification of cells and are promising sensitive biosensors. This technology could soon be successfully applied to planar configurations of pores, such as restrictions in microfluidic channels.
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Directions of work or proceedings, revue
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https://hal.laas.fr/hal-02382079
Contributor : Emeline Descamps <>
Submitted on : Wednesday, November 27, 2019 - 8:02:41 AM
Last modification on : Friday, November 20, 2020 - 1:00:06 PM

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Aurelie Bouchet-Spinelli, Emeline Descamps, Jie Liu, Abdulghani Ismail, Pascale Pham, et al.. Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology. Biosensors, 9 (4), pp.E121, 2019, ⟨10.3390/bios9040121⟩. ⟨hal-02382079⟩

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