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Impact of a chemical stimulus on two different cell lines through microwave dielectric spectroscopy at the single cell level

Abstract : Cellular analysis with microwave dielectric spectroscopy is gaining interest, as it presents attractive characteristics, such as being non-invasive, non-destructive, label-free, while cells may be analyzed directly into their culture medium. Most importantly, the microwave range enables intracellular investigations. This paper confirms such a capability through the evaluation of the different chemo-induced cell responses of two cell lines, HCT 166 and THP1. Moreover, this analyzing method does not only present different capacitive contrasts depending on cell lines. It also allows to extract distinct dielectric variations due to a chemical agent, which are attributed to different cell line-dependent internal modifications of the cells.
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https://hal.laas.fr/hal-02401032
Contributor : Katia Grenier <>
Submitted on : Monday, December 9, 2019 - 5:40:37 PM
Last modification on : Thursday, June 10, 2021 - 3:06:15 AM
Long-term archiving on: : Tuesday, March 10, 2020 - 10:56:02 PM

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Amar Tamra, M.-P. Rols, David Dubuc, Katia Grenier. Impact of a chemical stimulus on two different cell lines through microwave dielectric spectroscopy at the single cell level. IEEE MTT-S International Microwave Biomedical Conference (IMBioC 2019), May 2019, Nanjing, China. pp.1-4, ⟨10.1109/IMBIOC.2019.8777745⟩. ⟨hal-02401032⟩

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