Skip to Main content Skip to Navigation
Journal articles

Predicting secondary structure propensities in IDPs using simple statistics from three-residue fragments

Abstract : Intrinsically Disordered Proteins (IDPs) play key functional roles facilitated by their inherent plasticity. In most of the cases, IDPs recognize their partners through partially-structured elements inserted in fully-disordered chains. The identification and characterization of these elements is fundamental to understand the functional mechanisms of IDPs. Although several computational methods have been developed to identify order within disordered chains, most of the current secondary structure predictors are focused on globular proteins and are not necessarily appropriate for IDPs. Here, we present a comprehen-sible method, called Local Structural Propensity Predictor (LS2P), to predict secondary structure elements from IDP sequences. LS2P performs statistical analyses from a database of three-residue fragments extracted from coil regions of high-resolution protein structures. In addition to identifying scarcely populated helical and extended regions, the method pinpoints short stretches triggering β-turn formation or promoting α-helices. The simplicity of the method enables a direct connection between experimental observations and structural features encoded in IDP sequences.
Complete list of metadata

Cited literature [58 references]  Display  Hide  Download

https://hal.laas.fr/hal-02920302
Contributor : Juan Cortés <>
Submitted on : Monday, August 24, 2020 - 3:20:56 PM
Last modification on : Friday, January 8, 2021 - 5:14:15 PM
Long-term archiving on: : Tuesday, December 1, 2020 - 6:22:24 PM

Identifiers

Citation

Alejandro Estaña, Amélie Barozet, Assia Mouhand, Marc Vaisset, Christophe Zanon, et al.. Predicting secondary structure propensities in IDPs using simple statistics from three-residue fragments. Journal of Molecular Biology, Elsevier, 2020, 342 (19), pp.5447-5459. ⟨10.1016/j.jmb.2020.07.026⟩. ⟨hal-02920302⟩

Share

Metrics

Record views

169

Files downloads

47