PI3K functions as a hub in mechanotransduction - LAAS - Laboratoire d'Analyse et d'Architecture des Systèmes Accéder directement au contenu
Article Dans Une Revue Trends in Biochemical Sciences Année : 2021

PI3K functions as a hub in mechanotransduction

Résumé

Mammalian cells integrate different types of stimuli that govern their fate. These stimuli encompass biochemical as well as biomechanical cues (shear, tensile, and compressive stresses) that are usually studied separately. The phosphatidylinositol 3-kinase (PI3K) enzymes, producing signaling phosphoinositides at plasma and intracellular membranes, are key in intracellular signaling and vesicular trafficking pathways. Recent evidence in cancer research demonstrates that these enzymes are essential in mechanotransduction. Despite this, the importance of the integration of biomechanical cues and PI3K-driven biochemical signals is underestimated. In this opinion article, we make the hypothesis that modeling of biomechanical cues is critical to understand PI3K oncogenicity. We also identify known/missing knowledge in terms of isoform specificity and molecular pathways of activation, knowledge that is needed for clinical applications.
Fichier principal
Vignette du fichier
manuscript-v_accepted.pdf (592.3 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03252135 , version 1 (07-06-2021)

Identifiants

Citer

M. Di-Luoffo, Zacchari Ben-Meriem, P. Lefebvre, Morgan Delarue, Julie Guillermet-Guibert. PI3K functions as a hub in mechanotransduction. Trends in Biochemical Sciences, 2021, 46 (11), pp.878-888. ⟨10.1016/j.tibs.2021.05.005⟩. ⟨hal-03252135⟩
37 Consultations
67 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More