Skip to Main content Skip to Navigation
Journal articles

Wet spinning of a library of carbohydrate low molecular weight gels

Abstract : Hypothesis Recently, a low molecular weight hydrogel based on a carbohydrate alkyl amide has been successfully used as biomaterial for neuron cell culture and for 3D printing. Varying the molecular structure should make it possible to extend the library of carbohydrate low molecular weight hydrogels available for these applications and to improve their performances. Experiments Thirteen molecules easy to synthetize and designed to be potentially biocompatible were prepared. They are based on gluconamide, glucoheptonamide, galactonamide, glucamide, aliphatic chains and glycine. Their gelation in water was investigated in thermal conditions and wet spinning conditions, namely by dimethylsulfoxide-water exchange under injection. Findings Nine molecules give hydrogels in thermal conditions. By wet spinning, six molecules selfassemble fast enough, within few seconds, to form continous hydrogel filaments. Therefore, the method enables to shape by injection these mechanically fragile hydrogels, notably in the perspective of 3D printing. Depending on the molecular structure, persistent or soluble gel filaments are obtained. The microstructures are varied, featuring entangled ribbons, platelets or particles. In thermal gelation, molecules with a symmetrical polar head (galacto, glucoheptono) give flat ribbons and molecules with an asymmetrical polar head (gluco) give helical ribbons. The introduction of an extra glycine linker disturbs this trend.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03278411
Contributor : Juliette Fitremann Connect in order to contact the contributor
Submitted on : Monday, July 5, 2021 - 3:23:22 PM
Last modification on : Tuesday, October 19, 2021 - 11:18:16 PM
Long-term archiving on: : Wednesday, October 6, 2021 - 6:41:07 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-12-11

Please log in to resquest access to the document

Identifiers

Citation

Delphine Bordignon, Barbara Lonetti, Christophe Coudret, Pierre Roblin, Pierre Joseph, et al.. Wet spinning of a library of carbohydrate low molecular weight gels. Journal of Colloid and Interface Science, Elsevier, 2021, 603, pp.333 - 343. ⟨10.1016/j.jcis.2021.06.058⟩. ⟨hal-03278411⟩

Share

Metrics

Record views

200