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The diversity of molecular interactions involving intrinsically disordered proteins: A molecular modeling perspective

Abstract : Intrinsically Disordered Proteins and Regions (IDPs/IDRs) are key components of a multitude of biological processes. Conformational malleability enables IDPs/IDRs to perform very specialized functions that cannot be accomplished by globular proteins. The functional role for most of these proteins is related to the recognition of other biomolecules to regulate biological processes or as a part of signaling pathways. Depending on the extent of disorder, the number of interacting sites and the type of partner, very different architectures for the resulting assemblies are possible. More recently, molecular condensates with liquid-like properties composed of multiple copies of IDPs and nucleic acids have been proven to regulate key processes in eukaryotic cells. The structural and kinetic details of disordered biomolecular complexes are difficult to unveil experimentally due to their inherent conformational heterogeneity. Computational approaches, alone or in combination with experimental data, have emerged as unavoidable tools to understand the functional mechanisms of this elusive type of assemblies. The level of description used, all-atom or coarse-grained, strongly depends on the size of the molecular systems and on the timescale of the investigated mechanism. In this mini-review, we describe the most relevant architectures found for molecular interactions involving IDPs/IDRs and the computational strategies applied for their investigation.
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Submitted on : Thursday, July 8, 2021 - 4:01:57 PM
Last modification on : Friday, August 5, 2022 - 10:40:07 AM
Long-term archiving on: : Saturday, October 9, 2021 - 6:59:22 PM


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Ilinka Clerc, Amin Sagar, Alessandro Barducci, Nathalie Sibille, Pau Bernadó, et al.. The diversity of molecular interactions involving intrinsically disordered proteins: A molecular modeling perspective. Computational and Structural Biotechnology Journal, Elsevier, 2021, 19, pp.3817-3828. ⟨10.1016/j.csbj.2021.06.031⟩. ⟨hal-03281983⟩



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