A LOW-COST AND EASY TO USE SORTING DEVICE FOR THE SEPARATION OF EXTRACELLULAR VESICLES FROM COMPLEX FLUIDS

We propose a simple microfluidic device able to separate extracellular vesicles (EVs and exosomes) from a complex sample using a low cost and ready-to-use hydrodynamic filtration lab on chip. We have shown the efficient separation of biofunctionnaliszed nanoparticles mimicking platelets derived EVs (diameter 700 nm) from synthetic samples and from diluted whole blood. Separation yield and recovery yield have been measured > 96% and 100% respectively.

Mots clés

Hydrodynamic filtration lab-on-chip microlfuidic cell sorting extracellular vesicles

Domaines

Micro et nanotechnologies/Microélectronique Mécanique des fluides [physics.class-ph] Biotechnologies

Fichier principal

TAS2021_A low-cost and easy to use sorting device for the separation of extracellular vesicles from complex fluids_PILLEMONT.pdf (1.14 Mo)

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https://laas.hal.science/hal-03514431

Soumis le : jeudi 6 janvier 2022-11:53:15

Dernière modification le : samedi 16 décembre 2023-12:33:45

Archivage à long terme le : jeudi 7 avril 2022-19:00:28

Dates et versions

hal-03514431 , version 1 (06-01-2022)

Identifiants

HAL Id : hal-03514431 , version 1

Citer

Lyne Pillemont, Daniel Guneysu, Wilfrid Boireau, Céline Elie-Caille, Anne Marie Gué. A LOW-COST AND EASY TO USE SORTING DEVICE FOR THE SEPARATION OF EXTRACELLULAR VESICLES FROM COMPLEX FLUIDS. MicroTAS 2021, Amy E. Herr, Joel Voldman, Oct 2021, Palm Springs, United States. ⟨hal-03514431⟩

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UNIV-TLSE2 CNRS UNIV-FCOMTE UNIV-BM INSA-TOULOUSE LAAS FEMTO-ST UNIV-BM-THESE UT1-CAPITOLE LAAS-MICRO-NANO-BIO-TECHNOLOGIES LAAS-MILE LAAS-SYSTEMES-COMPLEXES INSA-GROUPE ANR TOULOUSE-INP UNIV-UT3 UT3-TOULOUSEINP RENATECH

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