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BioMEMS pour l'Analyse Biomoléculaire : de l'intérêt du confinement et de la réduction d'échelle pour la quantification directe de biomarqueurs

Thierry Leichle 1
1 LAAS-MEMS - Équipe Microsystèmes électromécaniques
LAAS - Laboratoire d'analyse et d'architecture des systèmes
Abstract : Personalized medicine holds the promise to greatly improve patient well-being and to lower the overall cost of medical care. To make this happen, there is an urge to develop new biosensing platforms for the absolute quantification of biomarkers in liquid biopsies with high sensitivity, specificity, portability and at a low cost. This thesis presents the technological toolbox that I have been developing during the last 10 years at LAAS-CNRS to try and provide new molecular analysis devices. More specifically, I propose solutions that take advantage of the size reduction inherent to bioMEMS: nanofluidics-embedded biosensors for kinetic study of molecular interactions, resonant MEMS biosensors for label free detection, and porous silicon membranes for on-chip sample preparation based on filtering and ion concentration polarization.
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Submitted on : Friday, November 29, 2019 - 8:14:51 AM
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Thierry Leichle. BioMEMS pour l'Analyse Biomoléculaire : de l'intérêt du confinement et de la réduction d'échelle pour la quantification directe de biomarqueurs. Micro et nanotechnologies/Microélectronique. Université Toulouse 3 Paul Sabatier (UT3 Paul Sabatier), 2019. ⟨tel-02385708⟩

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