H. E. Abaci, K. Gledhill, Z. Guo, A. M. Christiano, and M. L. Shuler, Pumpless microfluidic platform for drug testing on human skin equivalents, Lab Chip, vol.15, pp.882-888, 2015.

A. Accardo, M. C. Blatche, R. Courson, I. Loubinoux, C. Thibault et al., , 2017.

, Multiphoton Direct Laser Writing and 3D Imaging of Polymeric Freestanding Architectures for Cell Colonization, Small, vol.13

J. N. Adkins and K. J. Lumb, Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2, Proteins, vol.46, pp.1-7, 2002.

J. Adnane, R. J. Jackson, S. V. Nicosia, A. B. Cantor, W. J. Pledger et al., Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model, Oncogene, vol.19, pp.5338-5347, 2000.

N. Annabi, A. Tamayol, J. A. Uquillas, M. Akbari, L. E. Bertassoni et al., 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine, Adv Mater, vol.26, pp.85-123, 2014.

R. Aoki, M. Shoshkes-carmel, N. Gao, S. Shin, C. L. May et al., Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche, Cell Mol Gastroenterol Hepatol, vol.2, pp.175-188, 2016.

V. A. Arboleda, H. Lee, R. Parnaik, A. Fleming, A. Banerjee et al., Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome, Nat Genet, vol.44, pp.788-792, 2012.

K. Arcaute, B. K. Mann, and R. B. Wicker, Stereolithography of three-dimensional bioactive poly(ethylene glycol) constructs with encapsulated cells, Ann Biomed Eng, vol.34, pp.1429-1441, 2006.

S. Asfaha, Y. Hayakawa, A. Muley, S. Stokes, T. A. Graham et al., , p.von

J. Burstin, T. L. Mastracci, and D. L. Worthley, Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine, Cell Stem Cell, vol.16, pp.627-638, 2015.

G. H. Ashton, J. P. Morton, K. Myant, T. J. Phesse, R. A. Ridgway et al., Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling, Dev Cell, vol.19, pp.259-269, 2010.

A. Ayyaz, S. Kumar, B. Sangiorgi, B. Ghoshal, J. Gosio et al., Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell, Nature, 2019.

L. Azzolin, T. Panciera, S. Soligo, E. Enzo, S. Bicciato et al., YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response, Cell, vol.158, pp.157-170, 2014.

E. R. Bakker, L. Raghoebir, P. F. Franken, W. Helvensteijn, L. Van-gurp et al., Induced Wnt5a expression perturbs embryonic outgrowth and intestinal elongation, but is well-tolerated in adult mice, Dev Biol, vol.369, pp.91-100, 2012.

N. Barker, Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration, Nat Rev Mol Cell Biol, vol.15, pp.19-33, 2014.

N. Barker and H. Clevers, Tracking down the stem cells of the intestine: strategies to identify adult stem cells, Gastroenterology, vol.133, pp.1755-1760, 2007.

N. Barker, J. H. Van-es, J. Kuipers, P. Kujala, M. Van-den-born et al., Identification of stem cells in small intestine and colon by marker gene Lgr5, Nature, vol.449, pp.1003-1007, 2007.

F. M. Barriga, E. Montagni, M. Mana, M. Mendez-lago, X. Hernando-momblona et al., Restriction of intestinal stem cell expansion and the regenerative response by YAP, Cell Stem Cell, vol.20, pp.106-110, 2013.

J. Bart, R. Tiggelaar, M. Yang, S. Schlautmann, H. Zuilhof et al., Roomtemperature intermediate layer bonding for microfluidic devices, Lab Chip, vol.9, pp.3481-3488, 2009.

O. Basak, J. Beumer, K. Wiebrands, H. Seno, A. Van-oudenaarden et al., , 2017.

, Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells, Cell Stem Cell, vol.20, pp.177-190

P. Bastide, C. Darido, J. Pannequin, R. Kist, S. Robine et al., Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium, J Cell Biol, vol.178, pp.635-648, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00267010

E. Batlle, J. T. Henderson, H. Beghtel, M. M. Van-den-born, E. Sancho et al., Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB, Cell, vol.111, pp.251-263, 2002.

J. F. Beaulieu, Differential expression of the VLA family of integrins along the crypt-villus axis in the human small intestine, J Cell Sci, vol.102, pp.427-436, 1992.

J. Behrens, J. P. Von-kries, M. Kuhl, L. Bruhn, D. Wedlich et al., Functional interaction of beta-catenin with the transcription factor LEF-1, Nature, vol.382, pp.638-642, 1996.

J. Bellis, I. Duluc, B. Romagnolo, C. Perret, M. C. Faux et al., The tumor suppressor Apc controls planar cell polarities central to gut homeostasis, J Cell Biol, vol.198, pp.331-341, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00740860

Y. D. Benoit, C. Lussier, P. A. Ducharme, S. Sivret, L. M. Schnapp et al., Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism, Biol Cell, vol.101, pp.695-708, 2009.

Y. D. Benoit, F. Pare, C. Francoeur, D. Jean, E. Tremblay et al., Cooperation between HNF-1alpha, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell line, Am J Physiol Gastrointest Liver Physiol, vol.298, pp.504-517, 2010.

O. Bernard, Lim kinases, regulators of actin dynamics, Int J Biochem Cell Biol, vol.39, pp.1071-1076, 2007.

A. Besson, S. F. Dowdy, and J. M. Roberts, CDK inhibitors: cell cycle regulators and beyond, Dev Cell, vol.14, pp.159-169, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00319908

S. N. Bhatia and D. E. Ingber, Microfluidic organs-on-chips, Nat Biotechnol, vol.32, pp.760-772, 2014.

D. M. Bissell and J. G. Tilles, Morphology and function of cells of human embryonic liver in monolayer culture, J Cell Biol, vol.50, pp.222-231, 1971.

M. Bjerknes and H. Cheng, The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse, Am J Anat, vol.160, pp.51-63, 1981.

M. Bjerknes and H. Cheng, The stem-cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse, Am J Anat, vol.160, pp.77-91, 1981.

M. Bjerknes and H. Cheng, Clonal analysis of mouse intestinal epithelial progenitors, Gastroenterology, vol.116, pp.7-14, 1999.

M. Bjerknes and H. Cheng, Modulation of specific intestinal epithelial progenitors by enteric neurons, Proc Natl Acad Sci U S A, vol.98, pp.12497-12502, 2001.

M. Bjerknes and H. Cheng, Cell Lineage metastability in Gfi1-deficient mouse intestinal epithelium, Dev Biol, vol.345, pp.49-63, 2010.

M. Bjerknes, C. Khandanpour, T. Moroy, T. Fujiyama, M. Hoshino et al.,

J. Wang and M. G. Martin, Origin of the brush cell lineage in the mouse intestinal epithelium, Dev Biol, vol.362, pp.194-218, 2012.

P. Blache, M. Van-de-wetering, I. Duluc, C. Domon, P. Berta et al., SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes, J Cell Biol, vol.166, pp.37-47, 2004.
URL : https://hal.archives-ouvertes.fr/hal-00266987

D. Blondel and M. P. Lutolf, Bioinspired Hydrogels for 3D Organoid Culture, Chimia (Aarau), vol.73, pp.81-85, 2019.

S. J. Bray, Notch signalling: a simple pathway becomes complex, Nat Rev Mol Cell Biol, vol.7, pp.678-689, 2006.

D. T. Breault, I. M. Min, D. L. Carlone, L. G. Farilla, D. M. Ambruzs et al., Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells, Proc Natl Acad Sci U S A, vol.105, pp.10420-10425, 2008.

H. Brenner, M. Kloor, and C. P. Pox, Colorectal cancer, Lancet, vol.383, pp.1490-1502, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01404971

F. Brioude, A. Lacoste, I. Netchine, M. P. Vazquez, F. Auber et al., Beckwith-Wiedemann syndrome: growth pattern and tumor risk according to molecular mechanism, and guidelines for tumor surveillance, Horm Res Paediatr, vol.80, pp.457-465, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00991088

F. Brioude, I. Netchine, F. Praz, M. Le-jule, C. Calmel et al., Mutations of the Imprinted CDKN1C Gene as a Cause of the Overgrowth Beckwith-Wiedemann Syndrome: Clinical Spectrum and Functional Characterization, Hum Mutat, vol.36, pp.894-902, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01195734

F. Brioude, I. Oliver-petit, A. Blaise, F. Praz, S. Rossignol et al., CDKN1C mutation affecting the PCNA-binding domain as a cause of familial Russell Silver syndrome, J Med Genet, vol.50, pp.823-830, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00991085

X. Q. Brown, K. Ookawa, and J. Y. Wong, Evaluation of polydimethylsiloxane scaffolds with physiologically-relevant elastic moduli: interplay of substrate mechanics and surface chemistry effects on vascular smooth muscle cell response, Biomaterials, vol.26, pp.3123-3129, 2005.

S. J. Buczacki, H. I. Zecchini, A. M. Nicholson, R. Russell, L. Vermeulen et al., Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle, Circ Res, vol.495, pp.45-54, 2002.

A. Busanello, C. Battistelli, M. Carbone, C. Mostocotto, and R. Maione, MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure, Nucleic Acids Res, vol.40, pp.8266-8275, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-00957422

J. Cai, N. Zhang, Y. Zheng, R. F. De-wilde, A. Maitra et al., The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program, Genes Dev, vol.24, pp.2383-2388, 2010.

F. D. Camargo, S. Gokhale, J. B. Johnnidis, D. Fu, G. W. Bell et al., YAP1 increases organ size and expands undifferentiated progenitor cells, Curr Biol, vol.17, pp.2054-2060, 2007.

N. Cancer-genome-atlas, Comprehensive molecular characterization of human colon and rectal cancer, Nature, vol.487, pp.330-337, 2012.

A. G. Castano, M. Garcia-diaz, N. Torras, G. Altay, J. Comelles et al., Dynamic photopolymerization produces complex microstructures on hydrogels in a moldless approach to generate a 3D intestinal tissue model, Biofabrication, vol.11, p.25007, 2019.

R. A. Cavallo, R. T. Cox, M. M. Moline, J. Roose, G. A. Polevoy et al., Drosophila Tcf and Groucho interact to repress Wingless signalling activity, Nature, vol.395, pp.604-608, 1998.

S. Cervantes, T. P. Yamaguchi, and M. Hebrok, Wnt5a is essential for intestinal elongation in mice, Dev Biol, vol.326, pp.285-294, 2009.

F. K. Chan, J. Zhang, L. Cheng, D. N. Shapiro, A. Winoto et al., Three-dimensional photopatterning of hydrogels using stereolithography for long-term cell encapsulation, Mol Cell Biol, vol.15, pp.2062-2070, 1995.

R. Chang, J. Nam, and W. Sun, Effects of dispensing pressure and nozzle diameter on cell survival from solid freeform fabrication-based direct cell writing, Tissue Eng Part A, vol.14, pp.41-48, 2008.

T. S. Chang, M. J. Kim, K. Ryoo, J. Park, S. J. Eom et al., p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase, J Biol Chem, vol.278, pp.48092-48098, 2003.

C. S. Chen, M. Mrksich, S. Huang, G. M. Whitesides, and D. E. Ingber, Geometric control of cell life and death, Science, vol.276, pp.1425-1428, 1997.

F. Chen, H. Kook, R. Milewski, A. D. Gitler, M. M. Lu et al., Hop is an unusual homeobox gene that modulates cardiac development, Cell, vol.110, pp.713-723, 2002.

L. Chen, H. Z. An, and P. S. Doyle, Synthesis of Nonspherical Microcapsules through Controlled Polyelectrolyte Coating of Hydrogel Templates, vol.31, pp.9228-9235, 2015.

L. Chen, N. H. Toke, S. Luo, R. P. Vasoya, R. L. Fullem et al., A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity, Nat Genet, 2019.

H. Cheng and M. Bjerknes, Whole population cell kinetics and postnatal development of the mouse intestinal epithelium, Anat Rec, vol.211, pp.420-426, 1985.

H. Cheng and C. P. Leblond, Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell, Am J Anat, vol.141, pp.461-479, 1974.

H. Cheng and C. P. Leblond, Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types, Am J Anat, vol.141, pp.537-561, 1974.

A. F. Cheung, A. M. Carter, K. K. Kostova, J. F. Woodruff, D. Crowley et al., Complete deletion of Apc results in severe polyposis in mice, Oncogene, vol.29, pp.1857-1864, 2010.

A. M. Chin, D. R. Hill, M. Aurora, and J. R. Spence, Morphogenesis and maturation of the embryonic and postnatal intestine, Semin Cell Dev Biol, vol.66, pp.81-93, 2017.

B. G. Chung, L. A. Flanagan, S. W. Rhee, P. H. Schwartz, A. P. Lee et al., Human neural stem cell growth and differentiation in a gradient-generating microfluidic device, Lab Chip, vol.5, pp.401-406, 2005.

M. A. Ciemerych and P. Sicinski, Cell cycle in mouse development, Oncogene, vol.24, pp.2877-2898, 2005.

H. Clevers, The intestinal crypt, a prototype stem cell compartment, Nature, vol.154, pp.53-54, 2013.

C. M. Costello, J. Hongpeng, S. Shaffiey, J. Yu, N. K. Jain et al., , 2014.

, Synthetic small intestinal scaffolds for improved studies of intestinal differentiation, Biotechnol Bioeng, vol.111, pp.1222-1232

C. M. Costello, R. M. Sorna, Y. L. Goh, I. Cengic, N. K. Jain et al., Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis, Mol Pharm, vol.11, pp.1329-1337, 1990.

R. Cruz-acuna, M. Quiros, A. E. Farkas, P. H. Dedhia, S. Huang et al., Synthetic hydrogels for human intestinal organoid generation and colonic wound repair, Nat Cell Biol, vol.19, pp.1326-1335, 2017.

R. Cruz-acuna, M. Quiros, S. Huang, D. Siuda, J. R. Spence et al., , 2018.

, PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery, Nat Protoc, vol.13, pp.2102-2119

H. Cui, M. Nowicki, J. P. Fisher, and L. G. Zhang, 3D Bioprinting for Organ Regeneration, 2017.

X. Adv-healthc-mater-6.-cui and T. Boland, Human microvasculature fabrication using thermal inkjet printing technology, Biomaterials, vol.30, pp.6221-6227, 2009.

X. Cui, K. Breitenkamp, M. G. Finn, M. Lotz, and D. D. Lima, Direct human cartilage repair using three-dimensional bioprinting technology, Tissue Eng Part A, vol.18, pp.1304-1312, 2012.

W. De-lau, N. Barker, T. Y. Low, B. K. Koo, V. S. Li et al., Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling, Nature, vol.476, pp.293-297, 2011.

W. De-lau, W. C. Peng, P. Gros, and H. Clevers, The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength, Genes Dev, vol.28, pp.305-316, 2014.

M. De-robertis, E. Massi, M. L. Poeta, S. Carotti, S. Morini et al., The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies, J Carcinog, vol.10, pp.449-453, 2011.

C. M. Dekaney, A. S. Gulati, A. P. Garrison, M. A. Helmrath, and S. J. Henning, Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice, Am J Physiol Gastrointest Liver Physiol, vol.297, pp.461-470, 2009.

C. Deng, P. Zhang, J. W. Harper, S. J. Elledge, and P. Leder, Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control, Cell, vol.82, pp.675-684, 1995.

J. Deutsch, D. Motlagh, B. Russell, and T. A. Desai, Fabrication of microtextured membranes for cardiac myocyte attachment and orientation, J Biomed Mater Res, vol.53, pp.267-275, 2000.

G. Dontu, W. M. Abdallah, J. M. Foley, K. W. Jackson, M. F. Clarke et al., In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells, Genes Dev, vol.17, pp.1253-1270, 2003.

J. S. Dovey, S. J. Zacharek, C. F. Kim, and J. A. Lees, Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion, Proc Natl Acad Sci U S A, vol.105, pp.11857-11862, 2008.

J. L. Drury and D. J. Mooney, Hydrogels for tissue engineering: scaffold design variables and applications, Biomaterials, vol.24, pp.4337-4351, 2003.

K. E. Drzewiecki, J. N. Malavade, I. Ahmed, C. J. Lowe, and D. I. Shreiber, A thermoreversible, photocrosslinkable collagen bio-ink for free-form fabrication of scaffolds for regenerative medicine, Technology (Singap World Sci), vol.5, pp.185-195, 2017.

J. C. Dugas, A. Ibrahim, and B. A. Barres, A crucial role for p57(Kip2) in the intracellular timer that controls oligodendrocyte differentiation, J Neurosci, vol.27, pp.6185-6196, 2007.

N. Duquesnes, C. Callot, P. Jeannot, V. Daburon, K. I. Nakayama et al., p57(Kip2) knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann syndrome, J Pathol, vol.239, pp.250-261, 2016.

A. Durand, B. Donahue, G. Peignon, F. Letourneur, N. Cagnard et al., Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1), Proc Natl Acad Sci U S A, vol.109, pp.8965-8970, 2012.

J. S. Dutton, S. S. Hinman, R. Kim, Y. Wang, A. et al., Primary Cell-Derived Intestinal Models: Recapitulating Physiology, Trends Biotechnol, vol.37, pp.744-760, 2019.

C. D. Edington, W. L. Chen, E. Geishecker, T. Kassis, L. R. Soenksen et al., Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies, Eur J Hum Genet, vol.22, pp.614-622, 2014.

R. L. Ehrmann and G. O. Gey, The growth of cells on a transparent gel of reconstituted rattail collagen, J Natl Cancer Inst, vol.16, pp.1375-1403, 1956.

M. Eiraku, N. Takata, H. Ishibashi, M. Kawada, E. Sakakura et al., Self-organizing optic-cup morphogenesis in three-dimensional culture, Nature, vol.472, pp.51-56, 2011.

M. Eiraku, K. Watanabe, M. Matsuo-takasaki, M. Kawada, S. Yonemura et al., Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals, Glob Cardiol Sci Pract, vol.3, pp.316-342, 2008.

M. Elliott, R. Bayly, T. Cole, I. K. Temple, E. R. Maher et al., Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes, Clin Genet, vol.46, pp.316-328, 1977.

M. Escobar, P. Nicolas, F. Sangar, S. Laurent-chabalier, P. Clair et al., Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation, Nat Commun, vol.2, pp.340-343, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02459471

H. F. Farin, J. H. Van-es, and H. Clevers, Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells, Gastroenterology, vol.143, pp.1518-1529, 2012.

A. Fatehullah, S. H. Tan, and N. Barker, Organoids as an in vitro model of human development and disease, Nat Cell Biol, vol.18, pp.246-254, 2016.

N. S. Fearnhead, M. P. Britton, and W. F. Bodmer, The ABC of APC, Hum Mol Genet, vol.10, pp.721-733, 2001.

M. L. Fero, E. Randel, K. E. Gurley, J. M. Roberts, and C. J. Kemp, The murine gene p27Kip1 is haplo-insufficient for tumour suppression, Nature, vol.396, pp.177-180, 1998.

R. Figliola, A. Busanello, G. Vaccarello, and R. Maione, Regulation of p57(KIP2) during muscle differentiation: role of Egr1, Sp1 and DNA hypomethylation, J Mol Biol, vol.380, pp.265-277, 2008.

G. V. Fitzpatrick, P. D. Soloway, and M. J. Higgins, Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1, Nat Genet, vol.32, pp.426-431, 2002.

D. J. Flanagan, T. J. Phesse, N. Barker, R. H. Schwab, N. Amin et al., Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells, Stem Cell Reports, vol.4, pp.759-767, 2015.

E. J. Formeister, A. L. Sionas, D. K. Lorance, C. L. Barkley, G. H. Lee et al., , 2009.

, Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium, Am J Physiol Gastrointest Liver Physiol, vol.296, pp.1108-1118

S. Fre, E. Hannezo, S. Sale, M. Huyghe, D. Lafkas et al., Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice, Int J Radiat Biol, vol.6, pp.849-871, 2005.

S. Furutachi, A. Matsumoto, K. I. Nakayama, and Y. Gotoh, p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis, EMBO J, vol.32, pp.970-981, 2013.

K. Furuyama, Y. Kawaguchi, H. Akiyama, M. Horiguchi, S. Kodama et al., Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine, Nat Genet, vol.43, pp.34-41, 2011.

D. Gagne, J. F. Groulx, Y. D. Benoit, N. Basora, E. Herring et al., , 2010.

, Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism, J Cell Physiol, vol.222, pp.387-400

B. Gao, Q. Yang, X. Zhao, G. Jin, Y. Ma et al., 4D Bioprinting for Biomedical Applications, vol.34, pp.746-756, 2016.

R. Gauvin, Y. C. Chen, J. W. Lee, P. Soman, P. Zorlutuna et al., Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography, Biomaterials, vol.33, pp.3824-3834, 2012.

S. Georgia, R. Soliz, M. Li, P. Zhang, and A. Bhushan, p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors, Dev Biol, vol.298, pp.22-31, 2006.

F. Gerbe, C. Legraverend, J. , and P. , The intestinal epithelium tuft cells: specification and function, Cell Mol Life Sci, vol.69, pp.2907-2917, 2012.
URL : https://hal.archives-ouvertes.fr/hal-02459464

F. Gerbe, E. Sidot, D. J. Smyth, M. Ohmoto, I. Matsumoto et al., Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites, Nature, vol.529, pp.226-230, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01940966

F. Gerbe, J. H. Van-es, L. Makrini, B. Brulin, G. Mellitzer et al., Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium, J Cell Biol, vol.192, pp.767-780, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02459483

C. D. Gildner, A. L. Lerner, and D. C. Hocking, Fibronectin matrix polymerization increases tensile strength of model tissue, Am J Physiol Heart Circ Physiol, vol.287, pp.46-53, 2004.

C. Giovannini, L. Gramantieri, M. Minguzzi, F. Fornari, P. Chieco et al.,

, CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma, Am J Pathol, vol.181, pp.413-422

N. Gjorevski, M. P. Lutolf, N. Gjorevski, N. Sachs, A. Manfrin et al., Synthesis and characterization of well-defined hydrogel matrices and their application to intestinal stem cell and organoid culture, Biotechnol Prog, vol.12, pp.1781-1785, 2003.

S. Gonzalez, M. M. Perez-perez, E. Hernando, M. Serrano, C. Cordon-cardo et al., Oligodendroglial maturation is dependent on intracellular protein shuttling, Cancer Res, vol.65, pp.906-919, 2005.

V. Grandjean, J. Smith, P. N. Schofield, F. , and A. C. , Increased IGF-II protein affects p57kip2 expression in vivo and in vitro: implications for Beckwith-Wiedemann syndrome, Proc Natl Acad Sci U S A, vol.97, pp.5279-5284, 2000.

R. A. Greenberg, R. C. Allsopp, L. Chin, G. B. Morin, and R. A. Depinho, Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation, Oncogene, vol.16, pp.1723-1730, 1998.

A. Gregorieff, Y. Liu, M. R. Inanlou, Y. Khomchuk, and J. L. Wrana, Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer, Nature, vol.526, pp.715-718, 2015.

A. Gregorieff, D. Pinto, H. Begthel, O. Destree, M. Kielman et al., Expression pattern of Wnt signaling components in the adult intestine, Gastroenterology, vol.129, pp.626-638, 2005.

A. Gregorieff, D. E. Stange, P. Kujala, H. Begthel, M. Van-den-born et al., The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium, Gastroenterology, vol.137, pp.1333-1345, 2009.

L. M. Griep, F. Wolbers, B. De-wagenaar, P. M. Ter-braak, B. B. Weksler et al., BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function, Biomed Microdevices, vol.15, pp.145-150, 2013.

B. C. Gross, J. L. Erkal, S. Y. Lockwood, C. Chen, and D. M. Spence, Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences, Anal Chem, vol.86, pp.3240-3253, 2014.

A. S. Grosse, M. F. Pressprich, L. B. Curley, K. L. Hamilton, B. Margolis et al., Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis, Development, vol.138, pp.4423-4432, 2011.

J. F. Groulx, D. Gagne, Y. D. Benoit, D. Martel, N. Basora et al., Collagen VI is a basement membrane component that regulates epithelial cell-fibronectin interactions, Matrix Biol, vol.30, pp.195-206, 2011.

K. L. Guan, C. W. Jenkins, Y. Li, M. A. Nichols, X. Wu et al.,

, Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function, Genes Dev, vol.8, pp.2939-2952

D. Guarnieri, A. De-capua, M. Ventre, A. Borzacchiello, C. Pedone et al., Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters, Acta Biomater, vol.6, pp.2532-2539, 2010.

F. Guillemot, A. Nagy, A. Auerbach, J. Rossant, and A. L. Joyner, Essential role of Mash-2 in extraembryonic development, Nature, vol.371, pp.333-336, 1994.

J. Guiu, E. Hannezo, S. Yui, S. Demharter, S. Ulyanchenko et al., Classification and functions of enteroendocrine cells of the lower gastrointestinal tract, Nature. Gunawardene, A.R, vol.92, pp.219-231, 2011.

H. G. Hall, D. A. Farson, and M. J. Bissell, Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture, Proc Natl Acad Sci U S A, vol.79, pp.4672-4676, 1982.

G. J. Hannon and D. Beach, p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest, Nature, vol.371, pp.257-261, 1994.

H. X. Hao, Y. Xie, Y. Zhang, O. Charlat, E. Oster et al., ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner, Nature, vol.485, pp.195-200, 2012.

A. P. Haramis, H. Begthel, M. Van-den-born, J. Van-es, S. Jonkheer et al., De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine, Science, vol.303, pp.1684-1686, 2004.

J. C. Hardwick, . Van-den, G. R. Brink, S. A. Bleuming, I. Ballester et al., Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon, Gastroenterology, vol.126, pp.111-121, 2004.

A. T. Hark, C. J. Schoenherr, D. J. Katz, R. S. Ingram, J. M. Levorse et al., CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus, Nature, vol.405, pp.486-489, 2000.

J. W. Harper, G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge, The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases, Cell, vol.75, pp.805-816, 1993.

R. G. Harrison, M. Greenman, F. P. Mall, J. , and C. , Observations of the living developing nerve fiber, The Anatomical Record, vol.1, pp.116-128, 1907.

Y. Hashimoto, K. Kohri, Y. Kaneko, H. Morisaki, T. Kato et al., , 1998.

, Critical role for the 310 helix region of p57(Kip2) in cyclin-dependent kinase 2 inhibition and growth suppression, J Biol Chem, vol.273, pp.16544-16550

N. Hattori, T. C. Davies, L. Anson-cartwright, and J. C. Cross, Periodic expression of the cyclin-dependent kinase inhibitor p57(Kip2) in trophoblast giant cells defines a G2-like gap phase of the endocycle, Mol Biol Cell, vol.11, pp.1037-1045, 2000.

X. C. He, J. Zhang, W. G. Tong, O. Tawfik, J. Ross et al., BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling, Nat Genet, vol.36, pp.1117-1121, 2004.

A. Heinen, D. Kremer, P. Gottle, F. Kruse, B. Hasse et al., The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination, Proc Natl Acad Sci U S A, vol.105, pp.8748-8753, 2008.

A. Heinen, D. Kremer, H. P. Hartung, and P. Kury, p57 kip2's role beyond Schwann cell cycle control, Cell Cycle, vol.7, pp.2781-2786, 2008.

D. L. Hern and J. A. Hubbell, Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing, J Biomed Mater Res, vol.39, pp.266-276, 1998.

J. Heuberger, F. Kosel, J. Qi, K. S. Grossmann, K. Rajewsky et al., , 2014.

, Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine, Proc Natl Acad Sci U S A, vol.111, pp.3472-3477

I. J. Hidalgo, T. J. Raub, and R. T. Borchardt, Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability, Gastroenterology, vol.96, pp.736-749, 1989.

C. Hiemstra, L. J. Aa, Z. Zhong, P. J. Dijkstra, and J. Feijen, Rapidly in situ-forming degradable hydrogels from dextran thiols through Michael addition, Biomacromolecules, vol.8, pp.1548-1556, 2007.

H. Hirai, M. F. Roussel, J. Y. Kato, R. A. Ashmun, and C. J. Sherr, Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6, Mol Cell Biol, vol.15, pp.2672-2681, 1995.

M. Hirata, F. Kugimiya, A. Fukai, S. Ohba, N. Kawamura et al., C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57, PLoS One, vol.4, pp.1151-1163, 2006.

A. W. Hong, Z. Meng, and K. L. Guan, The Hippo pathway in intestinal regeneration and disease, Nat Rev Gastroenterol Hepatol, vol.13, pp.324-337, 2016.

G. Hua, T. H. Thin, R. Feldman, A. Haimovitz-friedman, H. Clevers et al., Crypt base columnar stem cells in small intestines of mice are radioresistant, Gastroenterology, vol.143, pp.1266-1276, 2012.

D. Huh, G. A. Hamilton, and D. E. Ingber, From 3D cell culture to organs-on-chips, Trends Cell Biol, vol.21, pp.745-754, 2011.

D. Huh, B. D. Matthews, A. Mammoto, M. Montoya-zavala, H. Y. Hsin et al., Reconstituting organ-level lung functions on a chip, Science, vol.328, pp.1662-1668, 2010.

M. Imajo, M. Ebisuya, and E. Nishida, Dual role of YAP and TAZ in renewal of the intestinal epithelium, Nat Cell Biol, vol.17, pp.7-19, 2015.

F. Ishibashi, H. Shimizu, T. Nakata, S. Fujii, K. Suzuki et al., Contribution of ATOH1(+) Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium, Stem Cell Reports, vol.10, pp.27-42, 2018.

Y. Itoh, N. Masuyama, K. Nakayama, K. I. Nakayama, and Y. Gotoh, The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex, J Biol Chem, vol.282, pp.390-396, 2007.

S. Itzkovitz, A. Lyubimova, I. C. Blat, M. Maynard, J. Van-es et al., Single-molecule transcript counting of stem-cell markers in the mouse intestine, Nat Cell Biol, vol.14, pp.106-114, 2011.

J. J. Jacobs, K. Kieboom, S. Marino, R. A. Depinho, and M. Van-lohuizen, The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus, Nature, vol.397, pp.164-168, 1999.

J. J. Jadasz, F. J. Rivera, A. Taubert, M. Kandasamy, B. Sandner et al., p57kip2 regulates glial fate decision in adult neural stem cells, Development, vol.139, pp.3306-3315, 2012.

U. Jadhav, K. Nalapareddy, M. Saxena, N. K. O'neill, L. Pinello et al., Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells, Cell, vol.165, pp.1389-1400, 2016.

U. Jadhav, M. Saxena, N. K. O'neill, A. Saadatpour, G. C. Yuan et al., Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells, Cell Stem Cell, vol.21, pp.59-64, 2012.

K. J. Jang, A. P. Mehr, G. A. Hamilton, L. A. Mcpartlin, S. Chung et al., , 2013.

, Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment, Integr Biol (Camb), vol.5, pp.1119-1129

M. Jenny, C. Uhl, C. Roche, I. Duluc, V. Guillermin et al.,

G. Gradwohl, Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium, EMBO J, vol.21, pp.6338-6347, 2002.

J. Jia, M. Lin, L. Zhang, J. P. York, and P. Zhang, The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression, Mol Cell Biol, vol.27, pp.7236-7247, 2007.

M. Joaquin, A. Gubern, D. Gonzalez-nunez, J. Ruiz, E. Ferreiro et al., The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress, EMBO J, vol.31, pp.2952-2964, 2012.

M. Joaquin and R. J. Watson, The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclinbinding domain, J Biol Chem, vol.278, pp.44255-44264, 2003.

L. A. Johnson, E. S. Rodansky, K. L. Sauder, J. C. Horowitz, J. D. Mih et al., Matrix stiffness corresponding to strictured bowel induces a fibrogenic response in human colonic fibroblasts, Inflamm Bowel Dis, vol.19, pp.891-903, 2013.

J. C. Jones, C. D. Brindley, N. H. Elder, M. G. Myers, . Jr et al., Cellular Plasticity of Defa4(Cre)-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury, Cell Mol Gastroenterol Hepatol, vol.7, pp.533-554, 2018.

R. G. Jones, X. Li, P. D. Gray, J. Kuang, F. Clayton et al., Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality, J Cell Biol, vol.175, pp.505-514, 2006.

R. N. Jorissen, F. Walker, N. Pouliot, T. P. Garrett, C. W. Ward et al., , 2003.

, Epidermal growth factor receptor: mechanisms of activation and signalling, Exp Cell Res, vol.284, pp.31-53

B. Joseph, E. R. Andersson, P. Vlachos, E. Sodersten, L. Liu et al., p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells, Cell Death Differ, vol.16, pp.1256-1265, 2009.

B. Joseph, A. Wallen-mackenzie, G. Benoit, T. Murata, E. Joodmardi et al., p57(Kip2) cooperates with Nurr1 in developing dopamine cells, Proc Natl Acad Sci U S A, vol.100, pp.15619-15624, 2003.

A. M. Jubb, S. Chalasani, G. D. Frantz, R. Smits, H. I. Grabsch et al., Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia, Oncogene, vol.25, pp.3445-3457, 2006.

P. Juskova, A. Ollitrault, M. Serra, J. L. Viovy, and L. Malaquin, Resolution improvement of 3D stereo-lithography through the direct laser trajectory programming: Application to microfluidic deterministic lateral displacement device, Anal Chim Acta, vol.1000, pp.239-247, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01852019

L. T. Kaaij, M. Van-de-wetering, F. Fang, B. Decato, A. Molaro et al., DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus, Genome Biol, vol.14, pp.2206-2215, 2013.

T. Kamura, T. Hara, S. Kotoshiba, M. Yada, N. Ishida et al., Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation, Proc Natl Acad Sci U S A, vol.100, pp.10231-10236, 2003.

T. Kanaya, K. Hase, D. Takahashi, S. Fukuda, K. Hoshino et al., The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells, Nat Immunol, vol.13, pp.729-736, 2012.

H. Y. Kao, M. Downes, P. Ordentlich, and R. M. Evans, Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression, Genes Dev, vol.14, pp.55-66, 2000.

L. Karlsson, P. Lindahl, J. K. Heath, and C. Betsholtz, Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis, Development, vol.127, pp.3457-3466, 2000.

M. Kasendra, A. Tovaglieri, A. Sontheimer-phelps, S. Jalili-firoozinezhad, A. Bein et al., The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon, Development, vol.129, pp.2619-2628, 2002.

E. Kavanagh, J. , and B. , The hallmarks of CDKN1C (p57, KIP2) in cancer, Biochim Biophys Acta, vol.1816, pp.50-56, 2011.

E. Kavanagh, P. Vlachos, V. Emourgeon, J. Rodhe, J. et al., Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine, Cell Death Dis, vol.3, pp.131-135, 2003.

V. Keriquel, H. Oliveira, M. Remy, S. Ziane, S. Delmond et al., In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications, Acta Physiol (Oxf), vol.7, pp.17-33, 2012.

T. Kikuchi, M. Toyota, F. Itoh, H. Suzuki, T. Obata et al., Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors, Oncogene, vol.21, pp.2741-2749, 2002.

H. J. Kim, D. Huh, G. Hamilton, and D. E. Ingber, Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow, Lab Chip, vol.12, pp.2165-2174, 2012.

H. J. Kim and D. E. Ingber, Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation, Integr Biol (Camb), vol.5, pp.1130-1140, 2013.

H. J. Kim, H. Li, J. J. Collins, and D. E. Ingber, Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip, Proc Natl Acad Sci U S A, vol.113, pp.7-15, 2016.

M. Kim, T. Nakamoto, S. Nishimori, K. Tanaka, and T. Chiba, A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation, EMBO Rep, vol.9, pp.878-884, 2008.

S. H. Kim, M. Chi, B. Yi, S. H. Kim, S. Oh et al., Three-dimensional intestinal villi epithelium enhances protection of human intestinal cells from bacterial infection by inducing mucin expression, Integr Biol (Camb), vol.6, pp.1122-1131, 2014.

T. H. Kim, S. Escudero, and R. A. Shivdasani, Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells, Proc Natl Acad Sci U S A, vol.109, pp.3932-3937, 2012.

T. H. Kim, F. Li, I. Ferreiro-neira, L. L. Ho, A. Luyten et al., Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity, Nature, vol.506, pp.511-515, 2014.

Y. S. Kim and S. B. Ho, Intestinal goblet cells and mucins in health and disease: recent insights and progress, Curr Gastroenterol Rep, vol.12, pp.319-330, 2010.

M. Kitagawa, S. Hatakeyama, M. Shirane, M. Matsumoto, N. Ishida et al., An F-box protein, FWD1, mediates ubiquitindependent proteolysis of beta-catenin, EMBO J, vol.18, pp.2401-2410, 1999.

H. K. Kleinman and G. R. Martin, Matrigel: basement membrane matrix with biological activity, Semin Cancer Biol, vol.15, pp.378-386, 2005.

K. A. Knoop, N. Kumar, B. R. Butler, S. K. Sakthivel, R. T. Taylor et al., RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium, J Immunol, vol.183, pp.5738-5747, 2009.

L. Koch, A. Deiwick, S. Schlie, S. Michael, M. Gruene et al., Skin tissue generation by laser cell printing, Biotechnol Bioeng, vol.109, pp.1855-1863, 2012.

G. Kokkinis, F. Keplinger, I. Giouroudi, V. L. Kolachala, R. Bajaj et al., Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation, Biomicrofluidics, vol.7, pp.32965-32973, 2007.

D. B. Kolesky, R. L. Truby, A. S. Gladman, T. A. Busbee, K. A. Homan et al., 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs, Adv Mater, vol.26, pp.3124-3130, 2014.

B. K. Koo, H. S. Lim, H. J. Chang, M. J. Yoon, Y. Choi et al., Notch signaling promotes the generation of EphrinB1-positive intestinal epithelial cells, Gastroenterology, vol.137, pp.141-143, 2009.

B. K. Koo, M. Spit, I. Jordens, T. Y. Low, D. E. Stange et al., Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors, Nature, vol.488, pp.665-669, 2012.

V. Korinek, N. Barker, P. Moerer, E. Van-donselaar, G. Huls et al., , 1998.

, Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4, Nat Genet, vol.19, pp.379-383

C. Kosinski, V. S. Li, A. S. Chan, J. Zhang, C. Ho et al., Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors, Proc Natl Acad Sci U S A, vol.104, pp.15418-15423, 2007.

D. Kremer, A. Heinen, J. Jadasz, P. Gottle, K. Zimmermann et al., p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation, Proc Natl Acad Sci U S A, vol.106, pp.9087-9092, 2009.

F. Kuhnert, C. R. Davis, H. T. Wang, P. Chu, M. Lee et al., , 2004.

, Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1, Proc Natl Acad Sci U S A, vol.101, pp.266-271

D. V. Labarbera, B. G. Reid, B. H. Yoo, M. B. Laederich, M. Funes-duran et al., The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases, Expert Opin Drug Discov, vol.7, pp.47050-47056, 2004.

M. A. Lancaster and J. A. Knoblich, Organogenesis in a dish: modeling development and disease using organoid technologies, Science, vol.345, p.1247125, 2014.

M. A. Lancaster, M. Renner, C. A. Martin, D. Wenzel, L. S. Bicknell et al., Cerebral organoids model human brain development and microcephaly, Nature, vol.501, pp.373-379, 2013.

S. Lang, A. C. Von-philipsborn, A. Bernard, F. Bonhoeffer, M. Bastmeyer et al., Growth cone response to ephrin gradients produced by microfluidic networks, Tissue engineering. Mol Ther, vol.390, pp.12-15, 2000.

A. J. Langlands, A. A. Almet, P. L. Appleton, I. P. Newton, J. M. Osborne et al., , 2016.

C. R. Lee, A. J. Grodzinsky, and M. Spector, The effects of cross-linking of collagenglycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis, Biomaterials, vol.14, pp.3145-3154, 2001.

M. H. Lee, I. Reynisdottir, and J. Massague, Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution, Genes Dev, vol.9, pp.639-649, 1995.

W. Lee, T. G. Lee, and W. Koh, Grafting of Poly (acrylic acid) on the Poly, 2007.

, Hydrogel Using Surface-initiated Photopolymerization for Covalent Immobilization of Collagen, Journal of Industrial and Engineering Chemistry, vol.13, pp.1195-1200

P. A. Leighton, J. R. Saam, R. S. Ingram, C. L. Stewart, and S. M. Tilghman, An enhancer deletion affects both H19 and Igf2 expression, Genes Dev, vol.9, pp.2079-2089, 1995.

E. Leishman, J. M. Howard, G. E. Garcia, Q. Miao, A. T. Ku et al., Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18, Development, vol.140, pp.3809-3818, 2013.

C. Leung, S. H. Tan, and N. Barker, Recent Advances in Lgr5(+) Stem Cell Research, Trends Cell Biol, vol.28, pp.380-391, 2018.

J. Li, M. Chen, X. Fan, H. Zhou, N. Li-jeon et al., Recent advances in bioprinting techniques: approaches, applications and future prospects, J Transl Med, vol.14, 2002.

, Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device, Nat Biotechnol, vol.20, pp.826-830

J. Q. Li, F. Wu, H. Usuki, A. Kubo, T. Masaki et al., Loss of p57KIP2 is associated with colorectal carcinogenesis, Int J Oncol, vol.23, pp.1537-1543, 2003.

L. Li and H. Clevers, Coexistence of quiescent and active adult stem cells in mammals, Science, vol.327, pp.542-545, 2010.

N. Li, A. Nakauka-ddamba, J. Tobias, S. T. Jensen, and C. J. Lengner, Mouse Label-Retaining Cells Are Molecularly and Functionally Distinct From Reserve Intestinal Stem Cells, Gastroenterology, vol.151, pp.298-310, 2016.

N. Li, M. Yousefi, A. Nakauka-ddamba, R. Jain, J. Tobias et al., Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy, Stem Cell Reports, vol.3, pp.876-891, 2014.

V. S. Li, S. S. Ng, P. J. Boersema, T. Y. Low, W. R. Karthaus et al., Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex, Cell, vol.149, pp.1245-1256, 2012.

S. Lim and P. Kaldis, Cdks, cyclins and CKIs: roles beyond cell cycle regulation, Development, vol.140, pp.3079-3093, 2013.

J. U. Lind, T. A. Busbee, A. D. Valentine, F. S. Pasqualini, H. Yuan et al., Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing, Nat Mater, vol.16, pp.303-308, 2017.

C. A. Lindemans, M. Calafiore, A. M. Mertelsmann, M. H. O'connor, J. A. Dudakov et al., Interleukin-22 promotes intestinalstem-cell-mediated epithelial regeneration, Nature, vol.528, pp.560-564, 2015.

C. Liu, Y. Li, M. Semenov, C. Han, G. H. Baeg et al., Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism, Cell, vol.108, pp.837-847, 2002.

W. Liu, H. Li, S. H. Hong, G. P. Piszczek, W. Chen et al., Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice, Oncogene, vol.35, pp.5237-5247, 2016.

Y. H. Lo, E. Chung, Z. Li, Y. W. Wan, M. M. Mahe et al., Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine, Cell Mol Gastroenterol Hepatol, vol.3, pp.51-71, 2017.

C. Lopez-garcia, A. M. Klein, B. D. Simons, and D. J. Winton, Intestinal stem cell replacement follows a pattern of neutral drift, Science, vol.330, pp.822-825, 2010.

J. H. Luo, Y. Ding, R. Chen, G. Michalopoulos, J. Nelson et al., Genomewide methylation analysis of prostate tissues reveals global methylation patterns of prostate cancer, Am J Pathol, vol.182, pp.2028-2036, 2013.

M. P. Lutolf and J. A. Hubbell, Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition, Biomacromolecules, vol.4, pp.713-722, 2003.

M. P. Lutolf, G. P. Raeber, A. H. Zisch, N. Tirelli, and J. A. Hubbell, Cell-responsive synthetic hydrogels, Advanced materials, vol.15, pp.888-892, 2003.

Y. Ma, L. Chen, G. M. Wright, S. R. Pillai, S. P. Chellappan et al., CDKN1C negatively regulates RNA polymerase II C-terminal domain phosphorylation in an E2F1-dependent manner, J Biol Chem, vol.285, pp.9813-9822, 2010.

Y. Ma and W. D. Cress, Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity, Oncogene, vol.26, pp.3532-3540, 2007.

N. A. Mabbott, D. S. Donaldson, H. Ohno, I. R. Williams, and A. Mahajan, Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium, Mucosal Immunol, vol.6, pp.666-677, 2013.

D. Mademtzoglou, S. Alonso-martin, T. H. Chang, K. Bismuth, B. Drayton-libotte et al., A p57 conditional mutant allele that allows tracking of p57-expressing cells, Genesis, vol.55, 2017.

D. Mademtzoglou, Y. Asakura, M. J. Borok, S. Alonso-martin, P. Mourikis et al., Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells, J Cell Sci, vol.121, pp.2493-2502, 2008.

G. Mairet-coello, A. Tury, E. Van-buskirk, K. Robinson, M. Genestine et al., p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex, Development, vol.139, pp.475-487, 2012.

M. Malumbres and M. Barbacid, Mammalian cyclin-dependent kinases, Trends Biochem Sci, vol.30, pp.630-641, 2005.

M. Malumbres and M. Barbacid, Cell cycle, CDKs and cancer: a changing paradigm, Nat Rev Cancer, vol.9, pp.153-166, 2009.

C. Mandrycky, Z. Wang, K. Kim, and D. H. Kim, 3D bioprinting for engineering complex tissues, Biotechnol Adv, vol.34, pp.422-434, 2016.

M. S. Mannoor, Z. Jiang, T. James, Y. L. Kong, K. A. Malatesta et al., 3D printed bionic ears, Nano Lett, vol.13, pp.2634-2639, 2013.

J. Mao, B. M. Kim, M. Rajurkar, R. A. Shivdasani, and A. P. Mcmahon, Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract, Development, vol.137, pp.1721-1729, 2010.

J. Martin-caballero, J. M. Flores, P. Garcia-palencia, and M. Serrano, Tumor susceptibility of p21(Waf1/Cip1)-deficient mice, Cancer Res, vol.61, pp.6234-6238, 2001.

A. Matsumoto, K. Hashimoto, T. Yoshioka, H. Otani, A. Matsumoto et al., Occlusion and subsequent recanalization in early duodenal development of human embryos: integrated organogenesis and histogenesis through a possible epithelial-mesenchymal interaction, Anat Embryol (Berl), vol.205, pp.262-271, 2002.

S. Matsuoka, M. C. Edwards, C. Bai, S. Parker, P. Zhang et al., p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene, Genes Dev, vol.9, pp.650-662, 1995.

F. P. Melchels, J. Feijen, and D. W. Grijpma, A review on stereolithography and its applications in biomedical engineering, Biomaterials, vol.31, pp.6121-6130, 2010.

L. Meran, A. Baulies, V. S. Li, A. Merlos-suarez, and E. Batlle, Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components, Curr Opin Cell Biol, vol.7970385, pp.194-200, 2008.

C. Metcalfe, N. M. Kljavin, R. Ybarra, and F. J. De-sauvage, Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration, Cell Stem Cell, vol.14, pp.149-159, 2014.

S. Michael, H. Sorg, C. T. Peck, L. Koch, A. Deiwick et al., Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice, Exp Cell Res, vol.8, pp.70-78, 1975.

I. Mironi-harpaz, D. Y. Wang, S. Venkatraman, and D. Seliktar, Photopolymerization of cellencapsulating hydrogels: crosslinking efficiency versus cytotoxicity, Acta Biomater, vol.8, pp.1838-1848, 2012.

F. Mohammad, T. Mondal, N. Guseva, G. K. Pandey, and C. Kanduri, Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1, Development, vol.137, pp.2493-2499, 2010.

A. V. Molofsky, S. He, M. Bydon, S. J. Morrison, and R. Pardal, Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways, Genes Dev, vol.19, pp.1432-1437, 2005.

A. V. Molofsky, R. Pardal, T. Iwashita, I. K. Park, M. F. Clarke et al., Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation, Nature, vol.425, pp.962-967, 2003.

R. K. Montgomery, D. L. Carlone, C. A. Richmond, L. Farilla, M. E. Kranendonk et al., Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells, Proc Natl Acad Sci U S A, vol.108, pp.179-184, 2011.

Y. Mori-akiyama, M. Van-den-born, J. H. Van-es, S. R. Hamilton, H. P. Adams et al., SOX9 is required for the differentiation of paneth cells in the intestinal epithelium, Gastroenterology, vol.133, pp.539-546, 2007.

M. Moriyama, A. D. Durham, H. Moriyama, K. Hasegawa, S. Nishikawa et al., Multiple roles of Notch signaling in the regulation of epidermal development, Dev Cell, vol.14, pp.594-604, 2008.

L. Moroni, T. Boland, J. A. Burdick, C. De-maria, B. Derby et al., Biofabrication: A Guide to Technology and Terminology, Trends Biotechnol, vol.36, pp.384-402, 2018.

S. J. Morrison and J. Kimble, Asymmetric and symmetric stem-cell divisions in development and cancer, Nature, vol.441, pp.1068-1074, 2006.

J. Munoz, D. E. Stange, A. G. Schepers, M. Van-de-wetering, B. K. Koo et al., The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers, EMBO J, vol.31, pp.3079-3091, 2012.

S. V. Murphy, A. , and A. , 3D bioprinting of tissues and organs, Nat Biotechnol, vol.32, pp.773-785, 2014.

H. Nagahama, S. Hatakeyama, K. Nakayama, M. Nagata, K. Tomita et al., , 2001.

, Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development, Anat Embryol (Berl), vol.203, pp.77-87

Y. Nakao, H. Kimura, Y. Sakai, T. Fujii, K. Nakayama et al., Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors, Biomicrofluidics, vol.5, pp.707-720, 1996.

K. Nakayama and K. Nakayama, Cip/Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development, Bioessays, vol.20, pp.1020-1029, 1998.

F. J. Naya, H. P. Huang, Y. Qiu, H. Mutoh, F. J. Demayo et al., Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice, Genes Dev, vol.11, pp.2323-2334, 1997.

M. Neunlist, P. Aubert, S. Bonnaud, L. Van-landeghem, E. Coron et al., Enteric glia inhibit intestinal epithelial cell proliferation partly through a TGF-beta1-dependent pathway, Am J Physiol Gastrointest Liver Physiol, vol.292, pp.4307-4314, 2002.

J. W. Nichol, S. T. Koshy, H. Bae, C. M. Hwang, S. Yamanlar et al., Cellladen microengineered gelatin methacrylate hydrogels, Biomaterials, vol.31, pp.5536-5544, 2010.

C. Niehrs, The complex world of WNT receptor signalling, Nat Rev Mol Cell Biol, vol.13, pp.767-779, 2012.

L. Nigmatullina, M. Norkin, M. M. Dzama, B. Messner, S. Sayols et al., Id2 controls specification of Lgr5(+) intestinal stem cell progenitors during gut development, EMBO J, vol.36, pp.869-885, 2017.

R. Nusse and H. Clevers, Wnt/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities, Cell, vol.169, pp.985-999, 2017.

R. Nusse, H. E. Varmus, and E. Wieschaus, Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome, Nature, vol.31, pp.795-801, 1980.

R. W. Orkin, P. Gehron, E. B. Mcgoodwin, G. R. Martin, T. Valentine et al., A murine tumor producing a matrix of basement membrane, J Exp Med, vol.145, pp.204-220, 1977.

L. Otsuki and A. H. Brand, Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence, Science, vol.360, pp.99-102, 2018.

L. Otsuki and A. H. Brand, Dorsal-Ventral Differences in Neural Stem Cell Quiescence Are Induced by p57(KIP2)/Dacapo, Dev Cell, vol.49, pp.293-300, 2019.

A. J. Ouellette, Paneth cells and innate mucosal immunity, Curr Opin Gastroenterol, vol.26, pp.547-553, 2010.

F. Pampaloni, E. G. Reynaud, and E. H. Stelzer, The third dimension bridges the gap between cell culture and live tissue, Nat Rev Mol Cell Biol, vol.8, pp.839-845, 2007.

R. R. Pandey, T. Mondal, F. Mohammad, S. Enroth, L. Redrup et al., Kcnq1ot1 antisense noncoding RNA mediates lineagespecific transcriptional silencing through chromatin-level regulation, Clin Cancer Res, vol.32, pp.5403-5410, 2006.

H. C. Park, J. Boyce, J. Shin, B. Appel, I. K. Park et al., Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function, J Neurosci, vol.25, pp.302-305, 2003.

J. Park, B. K. Lee, G. S. Jeong, J. K. Hyun, C. J. Lee et al., Three-dimensional brainon-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease, Lab Chip, vol.15, pp.141-150, 2015.

S. B. Parker, G. Eichele, P. Zhang, A. Rawls, A. T. Sands et al., p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells, Science, vol.267, pp.1024-1027, 1995.

I. S. Pateras, K. Apostolopoulou, M. Koutsami, K. Evangelou, P. Tsantoulis et al., Downregulation of the KIP family members p27(KIP1) and p57(KIP2) by SKP2 and the role of methylation in p57(KIP2) inactivation in nonsmall cell lung cancer, Int J Cancer, vol.119, pp.2546-2556, 2006.

I. S. Pateras, K. Apostolopoulou, K. Niforou, A. Kotsinas, and G. , Kip"ing the cell under control. Mol Cancer Res, vol.57, issue.2, pp.1902-1919, 2009.

F. Pati, J. Gantelius, and H. A. Svahn, 3D Bioprinting of Tissue/Organ Models, Angew Chem Int Ed Engl, vol.55, pp.4650-4665, 2016.

L. Pellegrinet, V. Rodilla, Z. Liu, S. Chen, U. Koch et al., Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells, Gastroenterology, vol.140, pp.1230-1240, 2011.

N. Peppas, P. Bures, W. Leobandung, and H. Ichikawa, Hydrogels in pharmaceutical formulations, European journal of pharmaceutics and biopharmaceutics, vol.50, pp.27-46, 2000.

N. A. Peppas, J. Z. Hilt, A. Khademhosseini, and R. Langer, Hydrogels in biology and medicine: from molecular principles to bionanotechnology, Advanced materials, vol.18, pp.1345-1360, 2006.

R. F. Pereira and P. J. Bártolo, 3D photo-fabrication for tissue engineering and drug delivery, Engineering, vol.1, pp.90-112, 2015.

O. W. Petersen, L. Ronnov-jessen, A. R. Howlett, and M. J. Bissell, Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells, Proc Natl Acad Sci U S A, vol.89, pp.9064-9068, 1992.

A. C. Petrey and C. A. Motte, The extracellular matrix in IBD: a dynamic mediator of inflammation, Curr Opin Gastroenterol, vol.33, pp.234-238, 2017.

T. V. Petrova, A. Nykanen, C. Norrmen, K. I. Ivanov, L. C. Andersson et al., Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype, Cancer Cell, vol.13, pp.407-419, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00282904

E. A. Phelps, N. Landazuri, P. M. Thule, W. R. Taylor, and A. J. Garcia, Bioartificial matrices for therapeutic vascularization, Proc Natl Acad Sci U S A, vol.107, pp.3323-3328, 2010.

R. Pippa, L. Espinosa, G. Gundem, R. Garcia-escudero, A. Dominguez et al., p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes, Oncogene, vol.31, pp.4207-4220, 2012.

T. D. Pollard, W. C. Earnshaw, and J. Lippincott-schwartz, Cell Biology E-Book, 2007.

K. Polyak, M. H. Lee, H. Erdjument-bromage, A. Koff, J. M. Roberts et al., Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals, Cell, vol.78, pp.59-66, 1994.

C. S. Potten, Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation, Nature, vol.269, pp.518-521, 1977.

C. S. Potten, Stem cells in gastrointestinal epithelium: numbers, characteristics and death, Philos Trans R Soc Lond B Biol Sci, vol.353, pp.821-830, 1998.

C. S. Potten, W. J. Hume, P. Reid, and J. Cairns, The segregation of DNA in epithelial stem cells, Cell, vol.15, pp.899-906, 1978.

C. S. Potten, G. Owen, and D. Booth, Intestinal stem cells protect their genome by selective segregation of template DNA strands, J Cell Sci, vol.115, pp.2381-2388, 2002.

S. Pounds and M. A. Dyer, Statistical analysis of data from retroviral clonal experiments in the developing retina, Brain Res, vol.1192, pp.178-185, 2008.

L. J. Pourchet, A. Thepot, M. Albouy, E. J. Courtial, A. Boher et al., Human Skin 3D Bioprinting Using Scaffold-Free Approach, Adv Healthc Mater, vol.6, 2017.

A. E. Powell, Y. Wang, Y. Li, E. J. Poulin, A. L. Means et al., The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor, Cell, vol.149, pp.146-158, 2012.

Z. Qi, Y. Li, B. Zhao, C. Xu, Y. Liu et al., Downregulated CDKN1C/p57(kip2) drives tumorigenesis and associates with poor overall survival in breast cancer, Biochem Biophys Res Commun, vol.8, pp.187-193, 2017.

A. J. Quyn, P. L. Appleton, F. A. Carey, R. J. Steele, N. Barker et al., Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue, Cell Stem Cell, vol.6, pp.175-181, 2010.

V. Ramanan, M. A. Scull, T. P. Sheahan, C. M. Rice, and S. N. Bhatia, New Methods in Tissue Engineering: Improved Models for Viral Infection, Annu Rev Virol, vol.1, pp.475-499, 2014.

W. Reik and J. Walter, Genomic imprinting: parental influence on the genome, Nat Rev Genet, vol.2, pp.21-32, 2001.

E. G. Reynaud, M. Guillier, M. P. Leibovitch, and S. A. Leibovitch, Dimerization of the amino terminal domain of p57Kip2 inhibits cyclin D1-cdk4 kinase activity, Oncogene, vol.19, pp.1147-1152, 2000.

E. G. Reynaud, M. P. Leibovitch, L. A. Tintignac, K. Pelpel, M. Guillier et al., Stabilization of MyoD by direct binding to p57(Kip2), J Biol Chem, vol.275, pp.18767-18776, 2000.

E. G. Reynaud, K. Pelpel, M. Guillier, M. P. Leibovitch, and S. A. Leibovitch, p57(Kip2) stabilizes the MyoD protein by inhibiting cyclin E-Cdk2 kinase activity in growing myoblasts, Mol Cell Biol, vol.19, pp.7621-7629, 1999.

B. A. Reynolds and S. Weiss, Clonal and population analyses demonstrate that an EGFresponsive mammalian embryonic CNS precursor is a stem cell, Dev Biol, vol.175, pp.1-13, 1996.

J. G. Rheinwald and H. Green, Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells, Cell, vol.6, pp.331-343, 1975.

O. Riccio, M. E. Van-gijn, A. C. Bezdek, L. Pellegrinet, J. H. Van-es et al., Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2, EMBO Rep, vol.9, pp.377-383, 2008.

F. Rijsewijk, M. Schuermann, E. Wagenaar, P. Parren, D. Weigel et al., The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless, Cell, vol.50, pp.649-657, 1987.

L. Ritsma, S. I. Ellenbroek, A. Zomer, H. J. Snippert, F. J. De-sauvage et al., Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging, Nature, vol.507, pp.362-365, 2014.

P. Rizk and N. Barker, Gut stem cells in tissue renewal and disease: methods, markers, and myths, Wiley Interdiscip Rev Syst Biol Med, vol.4, pp.475-496, 2012.

S. Rodriguez, L. Wang, C. Mumaw, E. F. Srour, C. Lo-celso et al., , 2011.

, The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs, Blood, vol.117, pp.6509-6519

W. Roeb, A. Boyer, W. K. Cavenee, A. , and K. C. , PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1, Proc Natl Acad Sci U S A, vol.104, pp.18085-18090, 2007.

V. Romanelli, A. Belinchon, S. Benito-sanz, V. Martinez-glez, R. Gracia-bouthelier et al., CDKN1C (p57(Kip2)) analysis in Beckwith-Wiedemann syndrome (BWS) patients: Genotype-phenotype correlations, novel mutations, and polymorphisms, Am J Med Genet A, vol.152, pp.1390-1397, 2010.

G. Rossi, A. Manfrin, and M. P. Lutolf, Progress and potential in organoid research, Nat Rev Genet, vol.19, pp.671-687, 2018.

G. Rothschild, X. Zhao, A. Iavarone, and A. Lasorella, E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells, Mol Cell Biol, vol.26, pp.4351-4361, 2006.

F. Ruedinger, A. Lavrentieva, C. Blume, I. Pepelanova, and T. Scheper, Hydrogels for 3D mammalian cell culture: a starting guide for laboratory practice, Appl Microbiol Biotechnol, vol.99, pp.623-636, 2015.

A. A. Russo, P. D. Jeffrey, A. K. Patten, J. Massague, and N. P. Pavletich, Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex, Nature, vol.382, pp.325-331, 1996.

A. Sabnis, M. Rahimi, C. Chapman, and K. T. Nguyen, Cytocompatibility studies of an in situ photopolymerized thermoresponsive hydrogel nanoparticle system using human aortic smooth muscle cells, J Biomed Mater Res A, vol.91, pp.52-59, 2009.

S. Saha, E. Aranda, Y. Hayakawa, P. Bhanja, S. Atay et al., Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury, Nat Immunol, vol.7, pp.76-83, 2010.

M. K. Samuelsson, A. Pazirandeh, B. Davani, and S. Okret, p57Kip2, a glucocorticoidinduced inhibitor of cell cycle progression in HeLa cells, Mol Endocrinol, vol.13, pp.1811-1822, 1999.

M. K. Samuelsson, A. Pazirandeh, and S. Okret, A pro-apoptotic effect of the CDK inhibitor p57(Kip2) on staurosporine-induced apoptosis in HeLa cells, Biochem Biophys Res Commun, vol.296, pp.702-709, 2002.

R. Sancho, C. A. Cremona, and A. Behrens, Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease, EMBO Rep, vol.16, pp.571-581, 2015.

E. Sangiorgi and M. R. Capecchi, Bmi1 is expressed in vivo in intestinal stem cells, Nat Genet, vol.40, pp.915-920, 2008.

A. J. Santos, Y. H. Lo, A. T. Mah, and C. J. Kuo, The Intestinal Stem Cell Niche: Homeostasis and Adaptations, Trends Cell Biol, vol.28, pp.1062-1078, 2018.

N. Sasaki, N. Sachs, K. Wiebrands, S. I. Ellenbroek, A. Fumagalli et al., Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon, Proc Natl Acad Sci U S A, vol.113, pp.5399-5407, 2016.

T. Sato and H. Clevers, Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications, Science, vol.340, pp.1190-1194, 2013.

T. Sato, J. H. Van-es, H. J. Snippert, D. E. Stange, R. G. Vries et al., Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts, Nature, vol.469, pp.415-418, 2011.

T. Sato, R. G. Vries, H. J. Snippert, M. Van-de-wetering, N. Barker et al., Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche, Nature, vol.459, pp.262-265, 2009.

Y. Satoh, H. Nakadate, T. Nakagawachi, K. Higashimoto, K. Joh et al., Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumours, Br J Cancer, vol.95, pp.541-547, 2006.

R. E. Saunders, J. E. Gough, D. , and B. , Delivery of human fibroblast cells by piezoelectric drop-on-demand inkjet printing, Biomaterials, vol.29, pp.193-203, 2008.

J. M. Scandura, P. Boccuni, J. Massague, and S. D. Nimer, Transforming growth factor betainduced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation, Proc Natl Acad Sci U S A, vol.101, pp.15231-15236, 2004.

A. G. Schepers, R. Vries, M. Van-den-born, M. Van-de-wetering, and H. Clevers, Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes, EMBO J, vol.30, pp.1104-1109, 2011.

M. Schmitt, M. Schewe, A. Sacchetti, D. Feijtel, W. S. Van-de-geer et al., Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling, Cell Rep, vol.24, pp.2312-2328, 2018.

J. Schuijers, J. P. Junker, M. Mokry, P. Hatzis, B. K. Koo et al., Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts, Cell Stem Cell, vol.16, pp.158-170, 2015.

S. Schuller-ravoo, S. M. Teixeira, J. Feijen, D. W. Grijpma, and A. A. Poot, Flexible and elastic scaffolds for cartilage tissue engineering prepared by stereolithography using poly(trimethylene carbonate)-based resins, Macromol Biosci, vol.13, pp.1711-1719, 2013.

S. R. Schwarze, Y. Shi, V. X. Fu, P. A. Watson, and D. F. Jarrard, Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells, Oncogene, vol.20, pp.8184-8192, 2001.

M. Serrano, G. J. Hannon, and D. Beach, A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4, Nature, vol.366, pp.704-707, 1993.

E. R. Shamir and A. J. Ewald, Three-dimensional organotypic culture: experimental models of mammalian biology and disease, Nat Rev Mol Cell Biol, vol.15, pp.647-664, 2014.

K. L. Sheaffer, R. Kim, R. Aoki, E. N. Elliott, J. Schug et al., DNA methylation is required for the control of stem cell differentiation in the small intestine, Genes Dev, vol.28, pp.652-664, 2014.

C. J. Sherr and J. M. Roberts, CDK inhibitors: positive and negative regulators of G1-phase progression, Genes Dev, vol.13, pp.1501-1512, 1999.

W. Shin, C. D. Hinojosa, D. E. Ingber, and H. J. Kim, Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut, vol.15, pp.391-406, 2019.

M. Shoshkes-carmel, Y. J. Wang, K. J. Wangensteen, B. Toth, A. Kondo et al., Subepithelial telocytes are an important source of Wnts that supports intestinal crypts, Nature, vol.557, pp.242-246, 2018.

N. F. Shroyer, D. Wallis, K. J. Venken, H. J. Bellen, and H. Y. Zoghbi, Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation, Genes Dev, vol.19, pp.2412-2417, 2005.

M. Simian and M. J. Bissell, Organoids: A historical perspective of thinking in three dimensions, J Cell Biol, vol.216, pp.31-40, 2017.

M. Simian, Y. Hirai, M. Navre, Z. Werb, A. Lochter et al., The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells, Development, vol.128, pp.3117-3131, 2001.

R. Singhvi, A. Kumar, G. P. Lopez, G. N. Stephanopoulos, D. I. Wang et al., Engineering cell shape and function, Science, vol.264, pp.696-698, 1994.

A. Skardal, D. Mack, E. Kapetanovic, A. Atala, J. D. Jackson et al., , 2012.

, Bioprinted amniotic fluid-derived stem cells accelerate healing of large skin wounds, Stem Cells Transl Med, vol.1, pp.792-802

R. J. Smith, A. Rao-bhatia, T. H. Kim, H. J. Snippert, L. G. Van-der-flier et al., Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches, Wiley Interdiscip Rev Dev Biol, vol.6, pp.134-144, 2010.

H. J. Snippert, J. H. Van-es, M. Van-den-born, H. Begthel, D. E. Stange et al., Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine, Gastroenterology, vol.136, pp.2187-2194, 2009.

T. Srinivasan, E. B. Than, P. Bu, K. L. Tung, K. Y. Chen et al., Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells. Sci Rep 6, 26069, Cold Spring Harb Perspect Biol, vol.5, p.7898, 2013.

E. Stampone, I. Caldarelli, A. Zullo, D. Bencivenga, F. P. Mancini et al., Genetic and Epigenetic Control of CDKN1C Expression: Importance in Cell Commitment and Differentiation, Tissue Homeostasis and Human Diseases, Int J Mol Sci, vol.19, 2018.

G. Adler and M. Reinshagen, Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells, Gastroenterology, vol.124, pp.1748-1757, 2003.

M. C. Stewart, R. M. Kadlcek, P. D. Robbins, J. N. Macleod, and R. T. Ballock, Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation, J Bone Miner Res, vol.19, pp.123-132, 2004.

E. E. Storm, S. Durinck, F. De-sousa-e-melo, J. Tremayne, N. Kljavin et al., Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function, Nature, vol.529, pp.97-100, 2016.

C. H. Streuli, N. Bailey, and M. J. Bissell, Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity, J Cell Biol, vol.115, pp.1383-1395, 1991.

I. Stzepourginski, G. Nigro, J. M. Jacob, S. Dulauroy, P. J. Sansonetti et al.,

, CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury, Proc Natl Acad Sci U S A, vol.114, pp.506-513

H. N. Suh, M. J. Kim, Y. S. Jung, E. M. Lien, S. Jun et al., Quiescence Exit of Tert(+) Stem Cells by Wnt/beta-Catenin Is Indispensable for Intestinal Regeneration, Cell Rep, vol.21, p.185, 2017.

J. H. Sung, J. Yu, D. Luo, M. L. Shuler, and J. C. March, Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model, Lab Chip, vol.11, pp.389-392, 2011.

R. Suryadinata, M. Sadowski, and B. Sarcevic, Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates, Biosci Rep, vol.30, pp.243-255, 2010.

E. Susaki, K. Nakayama, L. Yamasaki, and K. I. Nakayama, Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model, Proc Natl Acad Sci U S A, vol.106, pp.5192-5197, 2009.

R. M. Sutherland, J. A. Mccredie, and W. R. Inch, Growth of multicell spheroids in tissue culture as a model of nodular carcinomas, J Natl Cancer Inst, vol.46, pp.113-120, 1971.

R. Takada, Y. Satomi, T. Kurata, N. Ueno, S. Norioka et al., , 2006.

, Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion, Dev Cell, vol.11, pp.791-801

N. Takeda, R. Jain, M. R. Leboeuf, Q. Wang, M. M. Lu et al., Interconversion between intestinal stem cell populations in distinct niches, Science, vol.334, pp.1420-1424, 2011.

K. Tamai, M. Semenov, Y. Kato, R. Spokony, C. Liu et al., LDL-receptor-related proteins in Wnt signal transduction, Nature, vol.407, pp.530-535, 2000.

K. Tamai, X. Zeng, C. Liu, X. Zhang, Y. Harada et al., A mechanism for Wnt coreceptor activation, Mol Cell, vol.13, pp.149-156, 2004.

Y. Tateishi, A. Matsumoto, T. Kanie, E. Hara, K. Nakayama et al., , 2012.

, Development of mice without Cip/Kip CDK inhibitors, Biochem Biophys Res Commun, vol.427, pp.285-292

A. I. Teixeira, G. A. Abrams, P. J. Bertics, C. J. Murphy, and P. F. Nealey, Epithelial contact guidance on well-defined micro-and nanostructured substrates, J Cell Sci, vol.116, pp.1881-1892, 2003.

I. C. Teller and J. F. Beaulieu, Interactions between laminin and epithelial cells in intestinal health and disease, Expert Rev Mol Med, vol.3, pp.1-18, 2001.

P. W. Tetteh, O. Basak, H. F. Farin, K. Wiebrands, K. Kretzschmar et al., Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters, Cell Stem Cell, vol.18, pp.203-213, 2016.

P. W. Tetteh, H. F. Farin, and H. Clevers, Plasticity within stem cell hierarchies in mammalian epithelia, Trends Cell Biol, vol.25, pp.100-108, 2015.

J. T. Thomas, P. Canelos, F. P. Luyten, M. Moos, and . Jr, Xenopus SMOC-1 Inhibits bone morphogenetic protein signaling downstream of receptor binding and is essential for postgastrulation development in Xenopus, J Biol Chem, vol.284, pp.18994-19005, 2009.

J. A. Thomson, J. Itskovitz-eldor, S. S. Shapiro, M. A. Waknitz, J. J. Swiergiel et al., Embryonic stem cell lines derived from human blastocysts, Science, vol.282, pp.1145-1147, 1998.

H. Tian, B. Biehs, S. Warming, K. G. Leong, L. Rangell et al., A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable, Nature, vol.478, pp.255-259, 2011.

R. Timpl, H. Rohde, P. G. Robey, S. I. Rennard, J. M. Foidart et al., Laminin--a glycoprotein from basement membranes, J Biol Chem, vol.254, pp.9933-9937, 1979.

T. Tokino, T. Urano, T. Furuhata, M. Matsushima, T. Miyatsu et al., Characterization of the human p57KIP2 gene: alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis, Hum Genet, vol.97, pp.625-631, 1996.

G. Tomic, E. Morrissey, S. Kozar, S. Ben-moshe, A. Hoyle et al., Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration, Cell Stem Cell, vol.23, pp.436-443, 2018.

H. Toyoshima and T. Hunter, p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21, Cell, vol.78, pp.67-74, 1994.

A. Tsugu, K. Sakai, P. B. Dirks, S. Jung, R. Weksberg et al., Expression of p57(KIP2) potently blocks the growth of human astrocytomas and induces cell senescence, Am J Pathol, vol.157, pp.919-932, 2000.

Z. Ullah, M. J. Kohn, R. Yagi, L. T. Vassilev, and M. L. Depamphilis, Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity, Genes Dev, vol.22, pp.3024-3036, 2008.

T. Urano, H. Yashiroda, M. Muraoka, K. Tanaka, T. Hosoi et al., p57(Kip2) is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor beta1, J Biol Chem, vol.274, pp.12197-12200, 1999.

A. Urrios, C. Parra-cabrera, N. Bhattacharjee, A. M. Gonzalez-suarez, L. G. Rigat-brugarolas et al., 3D-printing of transparent bio-microfluidic devices in PEG-DA, Lab Chip, vol.16, pp.2287-2294, 2016.

G. Vaccarello, R. Figliola, S. Cramerotti, F. Novelli, and R. Maione, p57Kip2 is induced by MyoD through a p73-dependent pathway, J Mol Biol, vol.356, pp.578-588, 2006.

T. Valenta, B. Degirmenci, A. E. Moor, P. Herr, D. Zimmerli et al., Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis, Annu Rev Physiol, vol.15, pp.241-260, 2002.

L. G. Van-der-flier, J. Sabates-bellver, I. Oving, A. Haegebarth, M. De-palo et al., Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors, Gastroenterology, vol.132, pp.1918-1927, 2007.

J. H. Van-es, P. Jay, A. Gregorieff, M. E. Van-gijn, S. Jonkheer et al., Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation, Stem Cell Quiescence: Dynamism, Restraint, and Cellular Idling, vol.7, pp.213-225, 1998.

K. L. Vandussen, A. J. Carulli, T. M. Keeley, S. R. Patel, B. J. Puthoff et al., Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells, Development, vol.139, pp.215-223, 2010.

X. Varelas, B. W. Miller, R. Sopko, S. Song, A. Gregorieff et al., The Hippo pathway regulates Wnt/beta-catenin signaling, Dev Cell, vol.18, pp.579-591, 2010.

M. Verhulsel, M. Vignes, S. Descroix, L. Malaquin, D. M. Vignjevic et al., Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine intestinal development, Am J Physiol Gastrointest Liver Physiol, vol.35, pp.168-178, 2009.

P. Vlachos, J. , and B. , The Cdk inhibitor p57(Kip2) controls LIM-kinase 1 activity and regulates actin cytoskeleton dynamics, Oncogene, vol.28, pp.4175-4188, 2009.

P. Vlachos, U. Nyman, N. Hajji, J. , and B. , The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway, Cell Death Differ, vol.14, pp.1497-1507, 2007.

N. Volk, B. Lacy, J. Von-moltke, M. Ji, H. E. Liang et al., Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit, Gastrointest Endosc Clin N Am, vol.27, pp.221-225, 2016.

G. Vozzi, C. Flaim, A. Ahluwalia, and S. Bhatia, Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition, Biomaterials, vol.24, pp.2533-2540, 2003.

E. L. Wakeling, F. Brioude, O. Lokulo-sodipe, S. M. O'connell, J. Salem et al., Diagnosis and management of Silver-Russell syndrome: first international consensus statement, Nat Rev Endocrinol, vol.13, pp.105-124, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02006400

K. D. Walton, A. M. Freddo, S. Wang, and D. L. Gumucio, Generation of intestinal surface: an absorbing tale, Development, vol.143, pp.2261-2272, 2016.

K. D. Walton, A. Kolterud, M. J. Czerwinski, M. J. Bell, A. Prakash et al., Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi, Proc Natl Acad Sci U S A, vol.109, pp.15817-15822, 2012.

K. D. Walton, M. Whidden, A. Kolterud, S. K. Shoffner, M. J. Czerwinski et al., Villification in the mouse: Bmp signals control intestinal villus patterning, Development, vol.143, pp.427-436, 2016.

F. Wang, V. M. Weaver, O. W. Petersen, C. A. Larabell, S. Dedhar et al., Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology, Proc Natl Acad Sci U S A, vol.95, pp.14821-14826, 1998.

L. Wang, S. K. Murthy, W. H. Fowle, G. A. Barabino, and R. L. Carrier, Influence of microwell biomimetic topography on intestinal epithelial Caco-2 cell phenotype, Biomaterials, vol.30, pp.6825-6834, 2009.

R. N. Wang, J. Green, Z. Wang, Y. Deng, M. Qiao et al., Bone Morphogenetic Protein (BMP) signaling in development and human diseases, Genes Dis, vol.1, pp.87-105, 2014.

Y. Wang, M. Disalvo, D. B. Gunasekara, J. Dutton, A. Proctor et al., Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells, Cell Mol Gastroenterol Hepatol, vol.4, pp.165-182, 2017.

Y. Wang, D. B. Gunasekara, M. I. Reed, M. Disalvo, S. J. Bultman et al., A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium, Biomaterials, vol.128, pp.44-55, 2017.

H. Watanabe, Z. Q. Pan, N. Schreiber-agus, R. A. Depinho, J. Hurwitz et al., , 1998.

, Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen, Proc Natl Acad Sci U S A, vol.95, pp.1392-1397

V. M. Weaver, O. W. Petersen, F. Wang, C. A. Larabell, P. Briand et al., Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies, J Cell Biol, vol.137, pp.231-245, 1997.

P. Wee, W. , and Z. , Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways, Cancers (Basel), p.9, 2017.

D. B. Weibel, W. R. Diluzio, and G. M. Whitesides, Microfabrication meets microbiology, Nat Rev Microbiol, vol.5, pp.209-218, 2007.

B. Weis, J. Schmidt, H. Maamar, A. Raj, H. Lin et al., Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a, Oncogene, vol.34, pp.1822-1830, 2015.

L. B. Weiswald, D. Bellet, and V. Dangles-marie, Spherical cancer models in tumor biology, Neoplasia, vol.17, pp.1-15, 2015.

R. Weksberg, C. Shuman, and J. B. Beckwith, Beckwith-Wiedemann syndrome, Eur J Hum Genet, vol.18, pp.8-14, 2010.
URL : https://hal.archives-ouvertes.fr/hal-01319105

J. Westbury, M. Watkins, A. C. Ferguson-smith, and J. Smith, Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis, Mech Dev, vol.109, pp.368-373, 2001.

K. Willert, J. D. Brown, E. Danenberg, A. W. Duncan, I. L. Weissman et al., Wnt proteins are lipid-modified and can act as stem cell growth factors, Nature, vol.423, pp.448-452, 2003.

H. Wilson, On some phenomena of coalescence and regeneration in sponges, Journal of Experimental Zoology, vol.5, pp.245-258, 1907.

V. W. Wong, D. E. Stange, M. E. Page, S. Buczacki, A. Wabik et al., Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling, Nat Cell Biol, vol.14, pp.401-408, 2012.

A. Yamada, M. Vignes, C. Bureau, A. Mamane, B. Venzac et al., In-mold patterning and actionable axo-somatic compartmentalization for on-chip neuron culture, Lab Chip, vol.16, pp.2059-2068, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01324932

M. Yamada, J. Udagawa, A. Matsumoto, R. Hashimoto, T. Hatta et al., Ror2 is required for midgut elongation during mouse development, Dev Dyn, vol.239, pp.941-953, 2010.

K. Yamamizu, T. Matsunaga, H. Uosaki, H. Fukushima, S. Katayama et al., Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors, J Cell Biol, vol.189, pp.325-338, 2010.

S. Yamazaki, A. Iwama, S. Takayanagi, K. Eto, H. Ema et al., TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation, Blood, vol.113, pp.1250-1256, 2009.

K. S. Yan, L. A. Chia, X. Li, A. Ootani, J. Su et al., The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations, Proc Natl Acad Sci U S A, vol.109, pp.466-471, 2012.

K. S. Yan, O. Gevaert, G. X. Zheng, B. Anchang, C. S. Probert et al., Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity, Cell Stem Cell, vol.21, pp.78-90, 2017.

Y. Yan, J. Frisen, M. H. Lee, J. Massague, and M. Barbacid, Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development, Genes Dev, vol.11, pp.973-983, 1997.

Q. Yang, N. A. Bermingham, M. J. Finegold, and H. Y. Zoghbi, Requirement of Math1 for secretory cell lineage commitment in the mouse intestine, Science, vol.294, pp.2155-2158, 2001.

W. Yang, H. Yu, W. Liang, Y. Wang, and L. Liu, Rapid fabrication of hydrogel microstructures using UV-induced projection printing, vol.6, pp.1903-1913, 2015.

X. Yang, R. K. Karuturi, F. Sun, M. Aau, K. Yu et al., , 2009.

D. Yimlamai, C. Christodoulou, G. G. Galli, K. Yanger, B. Pepe-mooney et al., CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells, PLoS One, vol.4, pp.1324-1338, 2014.

X. Yin, B. E. Mead, H. Safaee, R. Langer, J. M. Karp et al., Engineering Stem Cell Organoids, Cell Stem Cell, vol.18, pp.25-38, 2016.

T. Yokoo, H. Toyoshima, M. Miura, Y. Wang, K. T. Iida et al., p57Kip2 regulates actin dynamics by binding and translocating LIMkinase 1 to the nucleus, J Biol Chem, vol.278, pp.52919-52923, 2003.

J. Yu, S. Peng, D. Luo, and J. C. March, In vitro 3D human small intestinal villous model for drug permeability determination, Biotechnol Bioeng, vol.109, pp.2173-2178, 2012.

S. Yu, K. Tong, Y. Zhao, I. Balasubramanian, G. S. Yap et al., Paneth Cell Multipotency Induced by Notch Activation following Injury, Cell Stem Cell, vol.23, pp.46-59, 2018.

H. Yuan, K. Xing, and H. Y. Hsu, Trinity of Three-Dimensional (3D) Scaffold, Vibration, and 3D Printing on Cell Culture Application: A Systematic Review and Indicating Future Direction, Bioengineering (Basel), p.5, 2018.

K. Yue, . Trujillo-de, G. Santiago, M. M. Alvarez, A. Tamayol et al., Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels, Biomaterials, vol.73, pp.254-271, 2015.

S. Yui, L. Azzolin, M. Maimets, M. T. Pedersen, R. P. Fordham et al., YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration, Cell Stem Cell, vol.22, pp.35-49, 2018.

S. J. Zacharek, C. M. Fillmore, A. N. Lau, D. W. Gludish, A. Chou et al., Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci, Cell Stem Cell, vol.9, pp.272-281, 2011.

A. Zalc, S. Hayashi, F. Aurade, D. Brohl, T. Chang et al., Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest, Development, vol.141, pp.2780-2790, 2014.

X. Zeng, H. Huang, K. Tamai, X. Zhang, Y. Harada et al., Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions, Development, vol.135, pp.367-375, 2008.

B. Zhang, A. Korolj, B. F. Lai, and M. Radisic, Advances in organ-on-a-chip engineering, Nature Reviews Materials, vol.1, 2018.

J. Zhang, W. L. Liu, D. C. Tang, L. Chen, M. Wang et al., , 2002.

, Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development, Gene, vol.283, pp.83-93

N. Zhang, R. K. Yantiss, H. S. Nam, Y. Chin, X. K. Zhou et al., ID1 is a functional marker for intestinal stem and progenitor cells required for normal response to injury, Stem Cell Reports, vol.3, pp.716-724, 2014.

P. Zhang, N. J. Liegeois, C. Wong, M. Finegold, H. Hou et al., Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome, Nature, vol.387, pp.151-158, 1997.

P. Zhang, C. Wong, R. A. Depinho, J. W. Harper, and S. J. Elledge, Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development, Genes Dev, vol.12, pp.3162-3167, 1998.

P. Zhang, C. Wong, D. Liu, M. Finegold, J. W. Harper et al., p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step, Genes Dev, vol.13, pp.213-224, 1999.

Y. Zhao, Y. Li, S. Mao, W. Sun, R. Yao et al., Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance, Proc Natl Acad Sci U S A, vol.7, pp.1312-1320, 2011.

J. Zhu, Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering, Biomaterials, vol.31, pp.4639-4656, 2010.

J. Zhu, J. A. Beamish, C. Tang, K. Kottke-marchant, and R. E. Marchant, Extracellular matrix-like cell-adhesive hydrogels from RGD-containing poly (ethylene glycol) diacrylate, Macromolecules, vol.39, pp.1305-1307, 2006.

J. Zhu, J. Hu, and R. Marchant, Biomimetic hydrogels as scaffolds for tissue-engineering applications, Biomimetic Biomaterials, pp.238-275, 2013.

J. Zhu and R. E. Marchant, Design properties of hydrogel tissue-engineering scaffolds, Expert Rev Med Devices, vol.8, pp.607-626, 2011.

J. Zhu, C. Tang, K. Kottke-marchant, and R. E. Marchant, Design and synthesis of biomimetic hydrogel scaffolds with controlled organization of cyclic RGD peptides, Bioconjug Chem, vol.20, pp.333-339, 2009.

L. Zhu, P. Gibson, D. S. Currle, Y. Tong, R. J. Richardson et al., Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation, Nature, vol.457, pp.603-607, 2009.

P. Zou, H. Yoshihara, K. Hosokawa, I. Tai, K. Shinmyozu et al., p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70, Cell Stem Cell, vol.9, pp.247-261, 2011.