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, La dernière étape de ce projet a donc été la mise en forme des hydrogels de Gal-C7. L'idée était ici premièrement de trouver un moyen pour essayer d'aligner les fibres d'hydrogel, pour ensuite orienter la croissance des neurones dans le gel

, Malheureusement cela s'est révélé infructueux puisque les tubes se bouchaient systématiquement. L'étude s'est alors portée sur une autre famille d'hydrogels -les glucamines -qui eux peuvent être extrudés directement grâce à leur propriété de thixotropie, qui est définie comme la variation réversible de la viscosité du gel sous l'effet d'une contrainte. Ce phénomène permet donc l'extrusion directe de l'hydrogel sans détruire son réseau tridimensionnel. Deux molécules

, En effet, le gélifiant est dissout dans un solvant organique avec qui il a beaucoup d'affinité et cette solution est ensuite extrudée dans un bain de « non-solvant » où le gélifiant est peu soluble, provoquant ainsi la formation des fibres constituant le gel lorsque le non-solvant diffuse dans l'autre. Dans notre cas, la molécule de Gal-C7 est dissoute dans du diméthylsulfoxyde (DMSO) et la solution est extrudée dans un bain d'eau ultra pure. L'eau et le DMSO sont des solvants miscibles mais le DMSO étant légèrement plus dense que l'eau, par gravité, celui-ci forme un flux continu lorsqu'il est extrudé à la verticale dans le bain. Le gel prend alors la forme d'un filament

Y. Ohsedo, M. Oono, K. Saruhashi, and H. Watanabe, Alkylamido-D-Glucamine-Based Gelators for the Generation of Thixotropic Gels, vol.4, pp.48554-48558, 2014.