ACETYLCHOLINESTERASE Dynamin 2 Myotonic Dystrophy type 1 Mouse model GABA Dilated cardiomyopathy AAV Acetylcholinesterase knockout mouse Skeletal muscle CTG repeat contractions CRISPRi Myotonic Dystrophy Type 1 Antisense oligonucleotide Humans CTG repeats Alternative splicing Dystrophin Desmin Cell model Neuron Myotonic dystrophy type 1 Dystrophie Myotonique Transgenic mouse model CMS Maximal force Heart failure Cardiac muscle Oligodendrocytes Cell penetrating peptide Dystrophie myotonique Quantitative microdialysis Antisense oligonucleotides Long read sequencing RNA interference Duchenne muscular dystrophy Myelin Glucocorticoid-receptor Muscular dystrophy CONGENITAL MYATHENIC SYNDROME Knockout In vivo Acute coronary syndrome Transcriptomics Astrocyte ARN KNOCKOUT MICE Hypoxia Centronuclear myopathy Glial cells Fibrosis Lc3 Myostatin MBNL Autophagy PacBio Therapy Myotonic dystrophy Exercise Muscle Myotonic dystrophy mouse models Cell culture model Gene editing Exercice Gene therapy PCR Cytoskeleton Thérapie génique Motoneuron Glutamate Astrocytes Transgenic mouse Male DM1 Heart Aging Diaphragm Mouse models Gene Therapy DMSXL mice Genotype phenotype correlation Animals Central nervous system Brain dysfunction CRISPR/Cas9 RNA splicing Brain Mice CTG repeat instability BIOLOGIE MOLECULAIRE Acetylcholinesterase deficiency DMPK GSK3␤ Expression Trinucleotide repeat expansion Glucocorticoids Intermediate filament Oligodendrocyte Myotonic Dystrophy RNA biology Trinucleotide Repeat Expansion