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Microwave dielectric spectroscopy for single cell irreversible electroporation monitoring

Abstract : This paper demonstrates the efficient use of microwave dielectric spectroscopy for single cell irreversible electroporation monitoring. The experimental results point out a high correlation (R 2 higher than 0.94) with biological gold standard technique based on flow cytometry, whereas microwave approach features several key advantages: marker-less, contact-less and in-liquid cell(s) monitoring. The developed microwave and microfluidic-based biosensor reveals an increase in the capacitance and the conductance of single cells under investigation subjected to irreversible electroporation reflecting an increase in cell damages, which is in great correlation with results routinely obtained in biology. More interestingly, the post electroporation damages of cell have been experimentally quantified over time, which makes the microwave dielectric spectroscopy a technique of interest for cell's electroporation researches.
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https://hal.laas.fr/hal-01951589
Contributor : Katia Grenier <>
Submitted on : Tuesday, December 11, 2018 - 3:08:06 PM
Last modification on : Thursday, June 10, 2021 - 3:03:07 AM
Long-term archiving on: : Tuesday, March 12, 2019 - 3:08:15 PM

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Amar Tamra, Marie Deburghgraeve, David Dubuc, Marie-Pierre Rols, Katia Grenier. Microwave dielectric spectroscopy for single cell irreversible electroporation monitoring. IEEE International Microwave Symposium (IMS 2016), May 2016, San Francisco, CA, United States. ⟨10.1109/MWSYM.2016.7540429⟩. ⟨hal-01951589⟩

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