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Systèmes microfluidiques modèles : Transport en milieux poreux, nano-objets et membranes biomimétiques sur puce

Pierre Joseph 1
1 LAAS-MILE - Équipe Micro-Nanofluidique pour les sciences de la vie et de l’environnement
LAAS - Laboratoire d'analyse et d'architecture des systèmes
Abstract : Microfluidics, controlling fluids in microfabricated chips, is a valuable tool for chemical or biological analysis; these are labs-on-chip. It also allows, thanks to simplified configurations, to dissect and better understand some complex situations encountered in porous natural or industrial environments, or biological systems. The manuscript presents a summary of my research at LAAS-CNRS, based essentially on such model systems. Fluid transport in a porous medium, in particular at the nanoscale, is studied by manufacturing a microfluidic or even nanofluidic network, mimicking imbibition, fluid evaporation, or the crystallization of salt in a rock, or the clogging of a filtration membrane. The transport of nano-objects is studied for different questions related to biotechnologies: sorting or concentrating the objects before their analysis; evaluating their fate in the bloodstream for the vectorization of drugs. The perspectives of this work concern: (1) fluid transport in porous media; (2) the exploitation of microfluidic technologies to manipulate cell membrane models, and thus study the mechanisms of their interactions with nano-objects; (3) shaping a hydrogel based on molecular self-assemblies to make a 3D cell culture support.
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https://hal.laas.fr/tel-02067183
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Submitted on : Thursday, March 14, 2019 - 9:42:30 AM
Last modification on : Thursday, June 10, 2021 - 3:03:45 AM
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Pierre Joseph. Systèmes microfluidiques modèles : Transport en milieux poreux, nano-objets et membranes biomimétiques sur puce. Micro et nanotechnologies/Microélectronique. Université Toulouse 3 Paul Sabatier (UT3 Paul Sabatier), 2019. ⟨tel-02067183⟩

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